General Information:

Id: 505 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
article
Reference: Leem JY et al.(2002) Presenilin 1 is required for maturation and cell surface accumulation of nicastrin. J. Biol. Chem. 277 [PMID: 11943765]

Interaction Information:

Comment Proteolytic processing of amyloid precursor protein generates beta-amyloid (Abeta) peptides that are deposited in senile plaques in brains of aged individuals and patients with Alzheimer's disease.
Formal Description
Interaction-ID: 14083

gene/protein

APP

increases_quantity of

gene/protein

Amyloid beta peptide

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