General Information:

Id: 504 (click here to show other Interactions for entry)
Diseases: Dementia, Lewy body - [OMIM]
Parkinson disease
Rattus norvegicus
neuroblastoma cell line B103
article
Reference: Spencer B et al.(2009) Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinsons and Lewy body diseases J. Neurosci. 29 [PMID: 19864570]

Interaction Information:

Comment Excess of alpha-synuclein in the cells seems to reduce autophagy response.
Formal Description
Interaction-ID: 2498

decreases_activity of

process

autophagy

Comment Excess of alpha-synuclein in the cells seems to reduce autophagy response.
Formal Description
Interaction-ID: 2499

gene/protein

SNCA

decreases_activity of

process

autophagy

if SNCA is overexpressed
Comment Beclin 1 increases rate of autophagy.
Formal Description
Interaction-ID: 2504

gene/protein

BECN1

increases_activity of

process

autophagy

Comment Rapamycin functions as activator of autophagy.
Formal Description
Interaction-ID: 2506

drug/chemical compound

Rapamycin

increases_activity of

process

autophagy

Comment Autophagy, induced by addition of rapamycin, reduces alpha-synuclein-aggregates.
Formal Description
Interaction-ID: 2507

process

autophagy

decreases_quantity of