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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	504 (click here to show other Interactions for entry)
Diseases:	Dementia, Lewy body - [OMIM] Parkinson disease
Organism:	Rattus norvegicus
Tissue/Cell line:	neuroblastoma cell line B103
Publication type:	article
Reference:	Spencer B et al.(2009) Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinsons and Lewy body diseases J. Neurosci. 29 [PMID: 19864570]

Interaction Information:

Comment	Excess of alpha-synuclein in the cells seems to reduce autophagy response.
Formal Description Interaction-ID: 2499	gene/protein SNCA decreases_activity of process autophagy if SNCA is overexpressed

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