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Diseases	Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	503 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Mus musculus
Publication type:	article
Reference:	Dzamko N et al.(2008) AMPK-independent pathways regulate skeletal muscle fatty acid oxidation J. Physiol. (Lond.) 586: 5819-5831 [PMID: 18845612]

Interaction Information:

Comment	Muscle contractions performed ex vivo, in situ or during treadmill exercise activate an alternative kinase capable of phosphorylating ACC2 Ser-221 and stimulating fatty acid oxidation in the absence of increases in AMPK activity. In summary the results demonstrate that AMPK is not essential for the regulation of fatty acid oxidation by AICAR or muscle contraction.
Formal Description Interaction-ID: 46070	process muscle contraction increases_activity of process fatty acid beta-oxidation without activation of AMPK

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