General Information:

Id: 503 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Reference: Dzamko N et al.(2008) AMPK-independent pathways regulate skeletal muscle fatty acid oxidation J. Physiol. (Lond.) 586: 5819-5831 [PMID: 18845612]

Interaction Information:

Comment Isolated extensor digitorum longus (EDL) and soleus (SOL) muscles from wild-type mice were incubated in the presence of etomoxir, an irreversible CPT-1 inhibitor. At rest etomixir had no significant effect on fatty acid oxidation; however, when etomoxir was included during muscle contraction fatty acid oxidation was reduced by 50 and 90% in EDL and SOL muscle, respectively, indicating the critical role of CPT-1 in the regulation of contraction-stimulated fatty acid oxidation.
Formal Description
Interaction-ID: 2494



affects_activity of

in skeletal muscle; during muscle contraction