CIDeRGeneral Information:
| Id: | 503 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| article | |
| Reference: | Dzamko N et al.(2008) AMPK-independent pathways regulate skeletal muscle fatty acid oxidation J. Physiol. (Lond.) 586: 5819-5831 [PMID: 18845612] |
Interaction Information:
| Comment | Isolated extensor digitorum longus (EDL) and soleus (SOL) muscles from wild-type mice were incubated in the presence of etomoxir, an irreversible CPT-1 inhibitor. At rest etomixir had no significant effect on fatty acid oxidation; however, when etomoxir was included during muscle contraction fatty acid oxidation was reduced by 50 and 90% in EDL and SOL muscle, respectively, indicating the critical role of CPT-1 in the regulation of contraction-stimulated fatty acid oxidation. |
|
Formal Description Interaction-ID: 2494 |
gene/protein affects_activity of process |