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Alzheimer disease
Amyotrophic lateral sclerosis
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COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
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	Field	Term

General Information:

Id:	503 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Mus musculus
Publication type:	article
Reference:	Dzamko N et al.(2008) AMPK-independent pathways regulate skeletal muscle fatty acid oxidation J. Physiol. (Lond.) 586: 5819-5831 [PMID: 18845612]

Interaction Information:

Comment	Defects in skeletal muscle fatty acid oxidation contribute to the pathogenesis of insulin resistance and obesity.
Formal Description Interaction-ID: 2473	process fatty acid beta-oxidation affects_activity of disease Insulin resistance in skeletal muscle

Comment	AICAR stimulated fatty acid oxidation in both wild-type and AMPK KD extensor digitorum longus (EDL) muscle, but not soleus (SOL) muscle.
Formal Description Interaction-ID: 2490	drug/chemical compound AICAR increases_activity of process fatty acid beta-oxidation in skeletal muscle (EDL); in wild-type and AMPK KD mice
Drugbank entries	Show/Hide entries for AICAR
Drugbank DB01700	Aicar not specified ATIC
Drugbank DB01700	Aicar not specified ATIC

Comment	AICAR stimulated fatty acid oxidation in both wild-type and AMPK KD extensor digitorum longus (EDL) muscle, but not soleus (SOL) muscle.
Formal Description Interaction-ID: 2491	drug/chemical compound AICAR NOT increases_activity of process fatty acid beta-oxidation in skeletal muscle (SOL); in wild-type and AMPK KD mice
Drugbank entries	Show/Hide entries for AICAR
Drugbank DB01700	Aicar not specified ATIC
Drugbank DB01700	Aicar not specified ATIC

Comment	Isolated extensor digitorum longus (EDL) and soleus (SOL) muscles from wild-type mice were incubated in the presence of etomoxir, an irreversible CPT-1 inhibitor. At rest etomixir had no significant effect on fatty acid oxidation; however, when etomoxir was included during muscle contraction fatty acid oxidation was reduced by 50 and 90% in EDL and SOL muscle, respectively, indicating the critical role of CPT-1 in the regulation of contraction-stimulated fatty acid oxidation.
Formal Description Interaction-ID: 2494	gene/protein CPT1B affects_activity of process fatty acid beta-oxidation in skeletal muscle; during muscle contraction

Comment	Muscle contractions performed ex vivo, in situ or during treadmill exercise activate an alternative kinase capable of phosphorylating ACC2 Ser-221 and stimulating fatty acid oxidation in the absence of increases in AMPK activity. In summary the results demonstrate that AMPK is not essential for the regulation of fatty acid oxidation by AICAR or muscle contraction.
Formal Description Interaction-ID: 46070	process muscle contraction increases_activity of process fatty acid beta-oxidation without activation of AMPK

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