General Information:

Id: 503 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Dzamko N et al.(2008) AMPK-independent pathways regulate skeletal muscle fatty acid oxidation J. Physiol. (Lond.) 586: 5819-5831 [PMID: 18845612]

Interaction Information:

Comment Defects in skeletal muscle fatty acid oxidation contribute to the pathogenesis of insulin resistance and obesity.
Formal Description
Interaction-ID: 2473

affects_activity of

disease

Insulin resistance

in skeletal muscle
Comment AICAR stimulated fatty acid oxidation in both wild-type and AMPK KD extensor digitorum longus (EDL) muscle, but not soleus (SOL) muscle.
Formal Description
Interaction-ID: 2490

drug/chemical compound

AICAR

increases_activity of

in skeletal muscle (EDL); in wild-type and AMPK KD mice
Drugbank entries Show/Hide entries for AICAR
Comment AICAR stimulated fatty acid oxidation in both wild-type and AMPK KD extensor digitorum longus (EDL) muscle, but not soleus (SOL) muscle.
Formal Description
Interaction-ID: 2491

drug/chemical compound

AICAR

NOT increases_activity of

in skeletal muscle (SOL); in wild-type and AMPK KD mice
Drugbank entries Show/Hide entries for AICAR
Comment Isolated extensor digitorum longus (EDL) and soleus (SOL) muscles from wild-type mice were incubated in the presence of etomoxir, an irreversible CPT-1 inhibitor. At rest etomixir had no significant effect on fatty acid oxidation; however, when etomoxir was included during muscle contraction fatty acid oxidation was reduced by 50 and 90% in EDL and SOL muscle, respectively, indicating the critical role of CPT-1 in the regulation of contraction-stimulated fatty acid oxidation.
Formal Description
Interaction-ID: 2494

gene/protein

CPT1B

affects_activity of

in skeletal muscle; during muscle contraction
Comment Muscle contractions performed ex vivo, in situ or during treadmill exercise activate an alternative kinase capable of phosphorylating ACC2 Ser-221 and stimulating fatty acid oxidation in the absence of increases in AMPK activity. In summary the results demonstrate that AMPK is not essential for the regulation of fatty acid oxidation by AICAR or muscle contraction.
Formal Description
Interaction-ID: 46070

increases_activity of

without activation of AMPK