General Information:

Id: 5,037 (click here to show other Interactions for entry)
Diseases: Schizophrenia - [OMIM]
Mammalia
review
Reference: Newell KA(2013) Metabotropic glutamate receptor 5 in schizophrenia: emerging evidence for the development of antipsychotic drugs Future Med Chem 5: 1471-1474 [PMID: 24024939]

Interaction Information:

Comment The dopamine D2 receptor and mGluR5 form heterodimers in the striatum, particularly at the corticostriatal glutamate synapse, suggesting a possible avenue for indirect effects of mGluR5 PAMs on striatal dopaminergic signaling.
Formal Description
Interaction-ID: 49706

gene/protein

DRD2

interacts (colocalizes) with

gene/protein

GRM5

in the striatum, particularly at the corticostriatal glutamate synapse
Drugbank entries Show/Hide entries for DRD2 or GRM5