General Information:

Id: 5,011 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000133 blood serum
article
Reference: Altmaier E et al.(2014) Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism Eur. J. Epidemiol. 29: 325-336 [PMID: 24816436]

Interaction Information:

Comment For the statins the resulting metabolites with the lowest p values were 1-arachidonoylglycerophosphocholine [LPC(20:4)], 1-arachidonoylglycerophosphoethanolamine [LPE(20:4)], isobutyrylcarnitine [C3-M], 1-docosahexaenoylglycerophosphocholine [LPC(22:6)], alpha-tocopherol, uridine (all increased), 7-alphahydroxy-3-oxo-4-cholestenoate, 1-palmitoylglycerophosphoinositol [LPI(16:0)], lathosterol and glycochenodeoxycholate (all decreased).
Formal Description
Interaction-ID: 49465

drug/chemical compound

Statin

increases_quantity of

drug/chemical compound

LysoPC(20:4)

Comment For the statins the resulting metabolites with the lowest p values were 1-arachidonoylglycerophosphocholine [LPC(20:4)], 1-arachidonoylglycerophosphoethanolamine [LPE(20:4)], isobutyrylcarnitine [C3-M], 1-docosahexaenoylglycerophosphocholine [LPC(22:6)], alpha-tocopherol, uridine (all increased), 7-alphahydroxy-3-oxo-4-cholestenoate, 1-palmitoylglycerophosphoinositol [LPI(16:0)], lathosterol and glycochenodeoxycholate (all decreased).
Formal Description
Interaction-ID: 49466

drug/chemical compound

Statin

increases_quantity of

drug/chemical compound

LysoPE(20:4)

in blood serum
Comment For the statins the resulting metabolites with the lowest p values were 1-arachidonoylglycerophosphocholine [LPC(20:4)], 1-arachidonoylglycerophosphoethanolamine [LPE(20:4)], isobutyrylcarnitine [C3-M], 1-docosahexaenoylglycerophosphocholine [LPC(22:6)], alpha-tocopherol, uridine (all increased), 7-alphahydroxy-3-oxo-4-cholestenoate, 1-palmitoylglycerophosphoinositol [LPI(16:0)], lathosterol and glycochenodeoxycholate (all decreased).
Formal Description
Interaction-ID: 49467

drug/chemical compound

Statin

decreases_quantity of

in blood serum
Comment For the statins the resulting metabolites with the lowest p values were 1-arachidonoylglycerophosphocholine [LPC(20:4)], 1-arachidonoylglycerophosphoethanolamine [LPE(20:4)], isobutyrylcarnitine [C3-M], 1-docosahexaenoylglycerophosphocholine [LPC(22:6)], alpha-tocopherol, uridine (all increased), 7-alphahydroxy-3-oxo-4-cholestenoate, 1-palmitoylglycerophosphoinositol [LPI(16:0)], lathosterol and glycochenodeoxycholate (all decreased).
Formal Description
Interaction-ID: 49468

drug/chemical compound

Statin

decreases_quantity of

drug/chemical compound

1-Palmitoylglycerophosphoinositol

in blood serum
Comment For the statins the resulting metabolites with the lowest p values were 1-arachidonoylglycerophosphocholine [LPC(20:4)], 1-arachidonoylglycerophosphoethanolamine [LPE(20:4)], isobutyrylcarnitine [C3-M], 1-docosahexaenoylglycerophosphocholine [LPC(22:6)], alpha-tocopherol, uridine (all increased), 7-alphahydroxy-3-oxo-4-cholestenoate, 1-palmitoylglycerophosphoinositol [LPI(16:0)], lathosterol and glycochenodeoxycholate (all decreased).
Formal Description
Interaction-ID: 49469

drug/chemical compound

Statin

decreases_quantity of

drug/chemical compound

Lathosterol

in blood serum
Comment For the statins the resulting metabolites with the lowest p values were 1-arachidonoylglycerophosphocholine [LPC(20:4)], 1-arachidonoylglycerophosphoethanolamine [LPE(20:4)], isobutyrylcarnitine [C3-M], 1-docosahexaenoylglycerophosphocholine [LPC(22:6)], alpha-tocopherol, uridine (all increased), 7-alphahydroxy-3-oxo-4-cholestenoate, 1-palmitoylglycerophosphoinositol [LPI(16:0)], lathosterol and glycochenodeoxycholate (all decreased).
Formal Description
Interaction-ID: 49470

drug/chemical compound

Statin

increases_quantity of

drug/chemical compound

Isobutyrylcarnitine

in blood serum
Comment For the statins the resulting metabolites with the lowest p values were 1-arachidonoylglycerophosphocholine [LPC(20:4)], 1-arachidonoylglycerophosphoethanolamine [LPE(20:4)], isobutyrylcarnitine [C3-M], 1-docosahexaenoylglycerophosphocholine [LPC(22:6)], alpha-tocopherol, uridine (all increased), 7-alphahydroxy-3-oxo-4-cholestenoate, 1-palmitoylglycerophosphoinositol [LPI(16:0)], lathosterol and glycochenodeoxycholate (all decreased).
Formal Description
Interaction-ID: 49471

drug/chemical compound

Statin

increases_quantity of

drug/chemical compound

LysoPC(22:6)

in blood serum
Comment For the statins the resulting metabolites with the lowest p values were 1-arachidonoylglycerophosphocholine [LPC(20:4)], 1-arachidonoylglycerophosphoethanolamine [LPE(20:4)], isobutyrylcarnitine [C3-M], 1-docosahexaenoylglycerophosphocholine [LPC(22:6)], alpha-tocopherol, uridine (all increased), 7-alphahydroxy-3-oxo-4-cholestenoate, 1-palmitoylglycerophosphoinositol [LPI(16:0)], lathosterol and glycochenodeoxycholate (all decreased).
Formal Description
Interaction-ID: 49472

drug/chemical compound

Statin

increases_quantity of

drug/chemical compound

alpha-Tocopherol

in blood serum
Comment For the statins the resulting metabolites with the lowest p values were 1-arachidonoylglycerophosphocholine [LPC(20:4)], 1-arachidonoylglycerophosphoethanolamine [LPE(20:4)], isobutyrylcarnitine [C3-M], 1-docosahexaenoylglycerophosphocholine [LPC(22:6)], alpha-tocopherol, uridine (all increased), 7-alphahydroxy-3-oxo-4-cholestenoate, 1-palmitoylglycerophosphoinositol [LPI(16:0)], lathosterol and glycochenodeoxycholate (all decreased).
Formal Description
Interaction-ID: 49473

drug/chemical compound

Statin

decreases_quantity of

drug/chemical compound

Glycochenodeoxycholate

in blood serum
Comment For the statins the resulting metabolites with the lowest p values were 1-arachidonoylglycerophosphocholine [LPC(20:4)], 1-arachidonoylglycerophosphoethanolamine [LPE(20:4)], isobutyrylcarnitine [C3-M], 1-docosahexaenoylglycerophosphocholine [LPC(22:6)], alpha-tocopherol, uridine (all increased), 7-alphahydroxy-3-oxo-4-cholestenoate, 1-palmitoylglycerophosphoinositol [LPI(16:0)], lathosterol and glycochenodeoxycholate (all decreased).
Formal Description
Interaction-ID: 49477

drug/chemical compound

Statin

increases_quantity of

drug/chemical compound

Uridine

in blood serum
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