General Information:

Id: 500
Diseases: Parkinson disease
Homo sapiens
BTO:0000567 HeLa cell
article
Reference: Exner N et al.(2007) Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J. Neurosci. 27 [PMID: 17989306]

Interaction Information:

Comment Cells treated with PINK1 siRNA showed altered cristae morphology compared with cells treated with control siRNA or without siRNA.
Formal Description
Interaction-ID: 2437

gene/protein

PINK1

affects_activity of

in mitochondria
Comment PINK1 knockdown causes mitochondrial fragmentation and reduced membrane potential.
Formal Description
Interaction-ID: 2453

gene/protein

PINK1

increases_activity of

in mitochondria
Comment PINK1 knockdown causes mitochondrial fragmentation and reduced membrane potential.
Formal Description
Interaction-ID: 2456

gene/protein

PINK1

decreases_activity of

Comment Parkin rescues PINK1 deficiency. Mitochondrial abnormalities induced by a PINK1 knockdown could be affected by parkin expression.
Formal Description
Interaction-ID: 2460

gene/protein

PARK2

affects_activity of

which has been induced by PINK1 knockdown
Comment Parkin rescues PINK1 deficiency. Mitochondrial abnormalities induced by a PINK1 knockdown could be affected by parkin expression.
Formal Description
Interaction-ID: 2695

gene/protein

PARK2

affects_activity of

gene/protein

PINK1