General Information:

Id: 499 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0002181 HEK-293T cell; BTO:0000567 HeLa cell
article
Reference: Narendra D et al.(2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183: 795-803 [PMID: 19029340]

Interaction Information:

Comment Parkin selectively induces mitophagy, which suggests that Parkin could maintain fidelity of mitochondria by activating the autophagy of dysfunctional mitochondria.
Formal Description
Interaction-ID: 9829

gene/protein

PARK2

decreases_activity of

by promoting autophagic degradation of mitochondria