General Information:

Id: 499 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0002181 HEK-293T cell; BTO:0000567 HeLa cell
article
Reference: Narendra D et al.(2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183: 795-803 [PMID: 19029340]

Interaction Information:

Comment Mitochondrial depolarization, induced by treatment of cells with the uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP), causes the redistribution of Parkin from the cytosol to the mitochondria.
Formal Description
Interaction-ID: 2431

drug/chemical compound

CCCP

increases_transport of

gene/protein

PARK2

into mitochondria