General Information:

Id: 4,998 (click here to show other Interactions for entry)
Diseases: Atherosclerosis
Cardiovascular disease
Homo sapiens
aortic endothelial cell (HAEC)
article
Reference: Ryoo S et al.(2011) OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling Atherosclerosis 214: 279-287 [PMID: 21130456]

Interaction Information:

Comment Pre-incubation of human aortic endothelial cells (HAEC) with either lovastatin or simvastatin resulted in nearly complete inhibition of arginase activation in OxLDL-stimulated HAEC.
Formal Description
Interaction-ID: 49377

drug/chemical compound

Lovastatin

decreases_activity of

gene/protein

ARG2

in OxLDL-stimulated human aortic endothelial cells (HAECs)
Drugbank entries Show/Hide entries for Lovastatin or ARG2