General Information:

Id: 496 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
BTO:0000011 3T3-L1 cell
article
Reference: Gauthier MS et al.(2008) AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance. J. Biol. Chem. 283 [PMID: 18390901]

Interaction Information:

Comment Isoproterenol treatment of 3T3-L1 adipocytes for 1 h led to a 25% increase in reactive oxygen species (ROS) generation.
Formal Description
Interaction-ID: 2466

drug/chemical compound

Isoproterenol

increases_quantity of

drug/chemical compound

Reactive oxygen species

in adipose tissue
Drugbank entries Show/Hide entries for Isoproterenol
Comment 3T3-L1 adipocytes were incubated with the competitive inhibitor of AMPK, compound C, this increased ROS production in 3T3-L1 adipocytes in a dose-dependent manner.
Formal Description
Interaction-ID: 2467

drug/chemical compound

Compound C

increases_quantity of

drug/chemical compound

Reactive oxygen species

in adipose tissue
Comment 1 h of isoproterenol stimulation in the presence of compound C resulted in a further 5-fold increase in ROS production.
Formal Description
Interaction-ID: 2468

drug/chemical compound

Isoproterenol

affects_quantity of

drug/chemical compound

Reactive oxygen species

Drugbank entries Show/Hide entries for Isoproterenol
Comment 1 h of isoproterenol stimulation in the presence of compound C resulted in a further 5-fold increase in ROS production.
Formal Description
Interaction-ID: 12771

drug/chemical compound

Compound C

affects_quantity of

drug/chemical compound

Reactive oxygen species

Comment Inhibition of AMPK activity with compound C increases ROS production and lipolysis.
Formal Description
Interaction-ID: 12772

drug/chemical compound

Compound C

increases_quantity of

drug/chemical compound

Reactive oxygen species