General Information:
Id: | 495 (click here to show other Interactions for entry) |
Diseases: |
Parkinson disease
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Homo sapiens | |
BTO:0000567 HeLa cell; BTO:0001009 PC-12 cell | |
article | |
Reference: | Pridgeon JW et al.(2007) PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol. 5: E172 [PMID: 17579517] |
Interaction Information:
Comment | Cells expressing exogenous wild-type PINK1 were much more resistant to H(2)O(2)-induced cell death. The pathogenic PINK1 mutation W437X significantly reduced the ability of PINK1 to protect against cell death and pathogenic mutations G309D and L347P not only abolished, but also exacerbated oxidative-stress-induced cell death. |
Formal Description Interaction-ID: 2380 |
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