General Information:

Id: 495
Diseases: Parkinson disease
Homo sapiens
BTO:0000567 HeLa cell; BTO:0001009 PC-12 cell
article
Reference: Pridgeon JW et al.(2007) PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol. 5: E172 [PMID: 17579517]

Interaction Information:

Comment PINK1 interacts with TRAP1.
Formal Description
Interaction-ID: 2353

gene/protein

PINK1

interacts (colocalizes) with

gene/protein

TRAP1

in mitochondria
Comment PINK1 colocalizes with TRAP1 in mitochondria. Colocalization was not affected by the pathogenic PINK1 mutations (G309D, W437X and L347P).
Formal Description
Interaction-ID: 2355

gene/protein

PINK1

is localized in

cellular component

mitochondrion

Comment PINK1 colocalizes with TRAP1 in mitochondria. Colocalization was not affected by the pathogenic PINK1 mutations (G309D, W437X and L347P).
Formal Description
Interaction-ID: 2357

gene/protein

TRAP1

is localized in

cellular component

mitochondrion

Comment PINK1 colocalizes with TRAP1 in mitochondria. Colocalization was not affected by the pathogenic PINK1 mutations (G309D, W437X and L347P).
Formal Description
Interaction-ID: 2359

gene/protein mutant

PINK1-p.G309D

interacts (colocalizes) with

gene/protein

TRAP1

in mitochondria
Comment PINK1 colocalizes with TRAP1 in mitochondria. Colocalization was not affected by the pathogenic PINK1 mutations (G309D, W437X and L347P).
Formal Description
Interaction-ID: 2361

gene/protein mutant

PINK1-p.W437X

interacts (colocalizes) with

gene/protein

TRAP1

in mitochondria
Comment PINK1 colocalizes with TRAP1 in mitochondria. Colocalization was not affected by the pathogenic PINK1 mutations (G309D, W437X and L347P).
Formal Description
Interaction-ID: 2362

gene/protein mutant

PINK1-p.L347P

interacts (colocalizes) with

gene/protein

TRAP1

in mitochondria
Comment PINK1 phosphorylates TRAP1. The pathogenic mutations G309D or L347P virtually abolished the kinase activity of PINK1. In contrast the kinase activity of mutant W437X was not significantly altered.
Formal Description
Interaction-ID: 2365

gene/protein

PINK1

increases_phosphorylation of

gene/protein

TRAP1

Comment PINK1 phosphorylates TRAP1. The pathogenic mutations G309D or L347P virtually abolished the kinase activity of PINK1. In contrast the kinase activity of mutant W437X was not significantly altered.
Formal Description
Interaction-ID: 2368

gene/protein mutant

PINK1-p.W437X

increases_phosphorylation of

gene/protein

TRAP1

Comment PINK1 phosphorylates TRAP1. The pathogenic mutations G309D or L347P virtually abolished the kinase activity of PINK1. In contrast the kinase activity of mutant W437X was not significantly altered.
Formal Description
Interaction-ID: 2369

gene/protein mutant

PINK1-p.G309D

NOT increases_phosphorylation of

gene/protein

TRAP1

Comment PINK1 phosphorylates TRAP1. The pathogenic mutations G309D or L347P virtually abolished the kinase activity of PINK1. In contrast the kinase activity of mutant W437X was not significantly altered.
Formal Description
Interaction-ID: 2370

gene/protein mutant

PINK1-p.L347P

NOT increases_phosphorylation of

gene/protein

TRAP1

Comment Cells expressing exogenous wild-type PINK1 were much more resistant to H(2)O(2)-induced cell death. The pathogenic PINK1 mutation W437X significantly reduced the ability of PINK1 to protect against cell death and pathogenic mutations G309D and L347P not only abolished, but also exacerbated oxidative-stress-induced cell death.
Formal Description
Interaction-ID: 2376

gene/protein

PINK1

decreases_activity of

process

neuron death

Comment Cells expressing exogenous wild-type PINK1 were much more resistant to H(2)O(2)-induced cell death. The pathogenic PINK1 mutation W437X significantly reduced the ability of PINK1 to protect against cell death and pathogenic mutations G309D and L347P not only abolished, but also exacerbated oxidative-stress-induced cell death.
Formal Description
Interaction-ID: 2379

gene/protein mutant

PINK1-p.G309D

increases_activity of

process

neuron death

Comment Cells expressing exogenous wild-type PINK1 were much more resistant to H(2)O(2)-induced cell death. The pathogenic PINK1 mutation W437X significantly reduced the ability of PINK1 to protect against cell death and pathogenic mutations G309D and L347P not only abolished, but also exacerbated oxidative-stress-induced cell death.
Formal Description
Interaction-ID: 2380

gene/protein mutant

PINK1-p.L347P

increases_activity of

process

neuron death

Comment Treatment of cells with H(2)O(2) induced cytochrome c release from mitochondria to the cytosol a crucial step in the mitochondrial apoptotic cascade.
Formal Description
Interaction-ID: 2383

drug/chemical compound

H2O2

increases_transport of

gene/protein

CYCS

into cytoplasm
Drugbank entries Show/Hide entries for CYCS
Comment Treatment of cells with H(2)O(2) induced cytochrome c release from mitochondria to the cytosol a crucial step in the mitochondrial apoptotic cascade.
Formal Description
Interaction-ID: 2384
Comment Treatment of cells with H(2)O(2) induced cytochrome c release from mitochondria to the cytosol a crucial step in the mitochondrial apoptotic cascade.
Formal Description
Interaction-ID: 2385

drug/chemical compound

H2O2

increases_activity of

Comment Overexpression of wild-type PINK1 under oxidative stress conditions caused a significant reduction in the release of cytochrome c.
Formal Description
Interaction-ID: 2387

gene/protein

PINK1

decreases_quantity of

gene/protein

CYCS

in cytoplasm; under stress conditions
Drugbank entries Show/Hide entries for CYCS
Comment Overexpression of wild-type PINK1 under oxidative stress conditions caused a significant reduction in the release of cytochrome c.
Formal Description
Interaction-ID: 2389

gene/protein

PINK1

decreases_activity of

under stress conditions
Comment PD-linked PINK1 mutation W347X abolished the ability of PINK1 to suppress H(2)O(2)-induced cytochrome c release. The pathogenic G309D and L347P mutations even accelerated cytochrome c release.
Formal Description
Interaction-ID: 2393

gene/protein mutant

PINK1-p.W437X

NOT decreases_activity of

under stress conditions
Comment PD-linked PINK1 mutation W347X abolished the ability of PINK1 to suppress H(2)O(2)-induced cytochrome c release. The pathogenic G309D and L347P mutations even accelerated cytochrome c release.
Formal Description
Interaction-ID: 2398

gene/protein mutant

PINK1-p.G309D

increases_activity of

under stress conditions
Comment PD-linked PINK1 mutation W347X abolished the ability of PINK1 to suppress H(2)O(2)-induced cytochrome c release. The pathogenic G309D and L347P mutations even accelerated cytochrome c release.
Formal Description
Interaction-ID: 2402

gene/protein mutant

PINK1-p.L347P

increases_activity of

under stress conditions