General Information:

Id: 4,938 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Tauopathy
Mus musculus
THY-Tau22 transgenic mouse
article
Reference: Laurent C et al.(2014) Beneficial effects of caffeine in a transgenic model of Alzheimers disease-like tau pathology Neurobiol. Aging 35: 2079-2090 [PMID: 24780254]

Interaction Information:

Comment Chronic caffeine intake reduces hippocampal Tau hyperphosphorylation and the level of some Tau fragments, mitigates neuro-inflammation and prevents subsequent memory impairments in a transgenic mouse model of tauopathy.
Formal Description
Interaction-ID: 48841

drug/chemical compound

Caffeine

decreases_quantity of

protein modification

MAPT-hyperphos

in hippocampus
Drugbank entries Show/Hide entries for Caffeine