General Information:

Id: 4,938 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Tauopathy
Mus musculus
THY-Tau22 transgenic mouse
article
Reference: Laurent C et al.(2014) Beneficial effects of caffeine in a transgenic model of Alzheimers disease-like tau pathology Neurobiol. Aging 35: 2079-2090 [PMID: 24780254]

Interaction Information:

Comment Nrf2, MnSOD and EAAT3 expressions were significantly upregulated in Tau mice, supporting the development of a compensatory antioxidant response to Tau pathology in THY-Tau22 mice. These expressions significantly returned to control levels in Tau mice treated with caffein.
Formal Description
Interaction-ID: 48838

drug/chemical compound

Caffeine

decreases_expression of

gene/protein

GABPA

in TAU mice; Nrf2, a transcription factor is known to coordinate cellular responses to oxidative stress in the brain.
Drugbank entries Show/Hide entries for Caffeine