General Information:

Id: 4,938
Diseases: Alzheimer disease - [OMIM]
Tauopathy
Mus musculus
THY-Tau22 transgenic mouse
article
Reference: Laurent C et al.(2014) Beneficial effects of caffeine in a transgenic model of Alzheimers disease-like tau pathology Neurobiol. Aging 35: 2079-2090 [PMID: 24780254]

Interaction Information:

Comment Chronic caffeine intake prevents from the development of spatial memory deficits in THY-Tau22 transgenic mice. Improved memory was associated with reduced hippocampal Tau phosphorylation and proteolytic fragments.
Formal Description
Interaction-ID: 48798

drug/chemical compound

Caffeine

increases_activity of

process

memory

Drugbank entries Show/Hide entries for Caffeine
Comment Chronic caffeine intake prevents from the development of spatial memory deficits in THY-Tau22 transgenic mice. Improved memory was associated with reduced hippocampal Tau phosphorylation and proteolytic fragments.
Formal Description
Interaction-ID: 48800

drug/chemical compound

Caffeine

decreases_activity of

Drugbank entries Show/Hide entries for Caffeine
Comment Chronic caffeine intake prevents from the development of spatial memory deficits in THY-Tau22 transgenic mice. Improved memory was associated with reduced hippocampal Tau phosphorylation and proteolytic fragments.
Formal Description
Interaction-ID: 48821

drug/chemical compound

Caffeine

decreases_quantity of

protein modification

MAPT-phos

in hippocampus
Drugbank entries Show/Hide entries for Caffeine
Comment Caffeine modulates hippocampal neuro-inflammatory and oxidative stress markers in THY-Tau22 mice. Markers of innate immunity (CD68, CD45, TLR2) and astrocytes (GFAP) as well as several pro-inflammatory cytokines (CCl4, CCl5 and TNFalpha) were significantly upregulated in the hippocampus of THY-Tau22 as compared to WT animals.
Formal Description
Interaction-ID: 48825

drug/chemical compound

Caffeine

increases_quantity of

gene/protein

CD68

in hippocampus; CD68 is a marker of innate immunity.
Drugbank entries Show/Hide entries for Caffeine
Comment Caffeine modulates hippocampal neuro-inflammatory and oxidative stress markers in THY-Tau22 mice. Markers of innate immunity (CD68, CD45, TLR2) and astrocytes (GFAP) as well as several pro-inflammatory cytokines (CCl4, CCl5 and TNFalpha) were significantly upregulated in the hippocampus of THY-Tau22 as compared to WT animals.
Formal Description
Interaction-ID: 48827

drug/chemical compound

Caffeine

increases_quantity of

gene/protein

PTPRC

in hippocampus; CD45 is a marker of innate immunity.
Drugbank entries Show/Hide entries for Caffeine
Comment Caffeine modulates hippocampal neuro-inflammatory and oxidative stress markers in THY-Tau22 mice. Markers of innate immunity (CD68, CD45, TLR2) and astrocytes (GFAP) as well as several pro-inflammatory cytokines (CCl4, CCl5 and TNFalpha) were significantly upregulated in the hippocampus of THY-Tau22 as compared to WT animals.
Formal Description
Interaction-ID: 48828

drug/chemical compound

Caffeine

increases_quantity of

gene/protein

TLR2

in hippocampus; TLR2 is a marker of innate immunity.
Drugbank entries Show/Hide entries for Caffeine or TLR2
Comment Caffeine modulates hippocampal neuro-inflammatory and oxidative stress markers in THY-Tau22 mice. Markers of innate immunity (CD68, CD45, TLR2) and astrocytes (GFAP) as well as several pro-inflammatory cytokines (CCl4, CCl5 and TNFalpha) were significantly upregulated in the hippocampus of THY-Tau22 as compared to WT animals.
Formal Description
Interaction-ID: 48829

drug/chemical compound

Caffeine

increases_expression of

gene/protein

CCL4

in hippocampus; CCL4 is a pro-inflammatory cytokine;
Drugbank entries Show/Hide entries for Caffeine
Comment Caffeine modulates hippocampal neuro-inflammatory and oxidative stress markers in THY-Tau22 mice. Markers of innate immunity (CD68, CD45, TLR2) and astrocytes (GFAP) as well as several pro-inflammatory cytokines (CCl4, CCl5 and TNFalpha) were significantly upregulated in the hippocampus of THY-Tau22 as compared to WT animals.
Formal Description
Interaction-ID: 48830

drug/chemical compound

Caffeine

increases_expression of

gene/protein

CCL5

in hippocampus; CCL5 is a pro-inflammatory cytokine;
Drugbank entries Show/Hide entries for Caffeine or CCL5
Comment Caffeine modulates hippocampal neuro-inflammatory and oxidative stress markers in THY-Tau22 mice. Markers of innate immunity (CD68, CD45, TLR2) and astrocytes (GFAP) as well as several pro-inflammatory cytokines (CCl4, CCl5 and TNFalpha) were significantly upregulated in the hippocampus of THY-Tau22 as compared to WT animals.
Formal Description
Interaction-ID: 48831

drug/chemical compound

Caffeine

increases_quantity of

gene/protein

GFAP

in hippocampus
Drugbank entries Show/Hide entries for Caffeine
Comment Markers of innate immunity (CD68, CD45, TLR2) and astrocytes (GFAP) as well as several pro-inflammatory cytokines (CCl4, CCl5 and TNFalpha) were significantly upregulated in the hippocampus of THY-Tau22 as compared to WT animals.
Formal Description
Interaction-ID: 48833

drug/chemical compound

Caffeine

increases_expression of

gene/protein

TNF

in hippocampus; TNFalpha is a pro-inflammatory cytokine;
Drugbank entries Show/Hide entries for Caffeine or TNF
Comment Nrf2, MnSOD and EAAT3 expressions were significantly upregulated in Tau mice, supporting the development of a compensatory antioxidant response to Tau pathology in THY-Tau22 mice. These expressions significantly returned to control levels in Tau mice treated with caffein.
Formal Description
Interaction-ID: 48834

organism model

THY-Tau22 transgenic mouse

increases_expression of

gene/protein

GABPA

Nrf2, a transcription factor is known to coordinate cellular responses to oxidative stress in the brain.
Comment Nrf2, MnSOD and EAAT3 expressions were significantly upregulated in Tau mice, supporting the development of a compensatory antioxidant response to Tau pathology in THY-Tau22 mice. These expressions significantly returned to control levels in Tau mice treated with caffein.
Formal Description
Interaction-ID: 48835

organism model

THY-Tau22 transgenic mouse

increases_expression of

gene/protein

SOD2

MnSOD is a NRF2 target gene.
Drugbank entries Show/Hide entries for SOD2
Comment Nrf2, MnSOD and EAAT3 expressions were significantly upregulated in Tau mice, supporting the development of a compensatory antioxidant response to Tau pathology in THY-Tau22 mice. These expressions significantly returned to control levels in Tau mice treated with caffein.
Formal Description
Interaction-ID: 48837

organism model

THY-Tau22 transgenic mouse

increases_expression of

gene/protein

SLC1A1

EAAT3 is a NRF2 target gene.
Drugbank entries Show/Hide entries for SLC1A1
Comment Nrf2, MnSOD and EAAT3 expressions were significantly upregulated in Tau mice, supporting the development of a compensatory antioxidant response to Tau pathology in THY-Tau22 mice. These expressions significantly returned to control levels in Tau mice treated with caffein.
Formal Description
Interaction-ID: 48838

drug/chemical compound

Caffeine

decreases_expression of

gene/protein

GABPA

in TAU mice; Nrf2, a transcription factor is known to coordinate cellular responses to oxidative stress in the brain.
Drugbank entries Show/Hide entries for Caffeine
Comment Nrf2, MnSOD and EAAT3 expressions were significantly upregulated in Tau mice, supporting the development of a compensatory antioxidant response to Tau pathology in THY-Tau22 mice. These expressions significantly returned to control levels in Tau mice treated with caffein.
Formal Description
Interaction-ID: 48839

drug/chemical compound

Caffeine

decreases_expression of

gene/protein

SOD2

in TAU mice; MnSOD is a NRF2 target gene.
Drugbank entries Show/Hide entries for Caffeine or SOD2
Comment Nrf2, MnSOD and EAAT3 expressions were significantly upregulated in Tau mice, supporting the development of a compensatory antioxidant response to Tau pathology in THY-Tau22 mice. These expressions significantly returned to control levels in Tau mice treated with caffein.
Formal Description
Interaction-ID: 48840

drug/chemical compound

Caffeine

decreases_expression of

gene/protein

SLC1A1

in TAU mice; EAAT3 is a NRF2 target gene.
Drugbank entries Show/Hide entries for Caffeine or SLC1A1
Comment Chronic caffeine intake reduces hippocampal Tau hyperphosphorylation and the level of some Tau fragments, mitigates neuro-inflammation and prevents subsequent memory impairments in a transgenic mouse model of tauopathy.
Formal Description
Interaction-ID: 48841

drug/chemical compound

Caffeine

decreases_quantity of

protein modification

MAPT-hyperphos

in hippocampus
Drugbank entries Show/Hide entries for Caffeine
Comment Chronic caffeine intake reduces hippocampal Tau hyperphosphorylation and the level of some Tau fragments, mitigates neuro-inflammation and prevents subsequent memory impairments in a transgenic mouse model of tauopathy.
Formal Description
Interaction-ID: 48842

drug/chemical compound

Caffeine

decreases_activity of

phenotype

neuroinflammation

in hippocampus
Drugbank entries Show/Hide entries for Caffeine
Comment Chronic caffeine intake reduces hippocampal Tau hyperphosphorylation and the level of some Tau fragments, mitigates neuro-inflammation and prevents subsequent memory impairments in a transgenic mouse model of tauopathy.
Formal Description
Interaction-ID: 48843

drug/chemical compound

Caffeine

decreases_activity of

in a transgenic mouse model of tauopathy
Drugbank entries Show/Hide entries for Caffeine
Comment Nrf2, MnSOD and EAAT3 expressions were significantly upregulated in Tau mice, supporting the development of a compensatory antioxidant response to Tau pathology in THY-Tau22 mice. These expressions significantly returned to control levels in Tau mice treated with caffein.
Formal Description
Interaction-ID: 50888

organism model

THY-Tau22 transgenic mouse

increases_activity of

disease

Tauopathy