General Information:

Id: 492 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
Reference: Park H et al.(2002) Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J. Biol. Chem. 277 [PMID: 12065578]

Interaction Information:

Comment The principal findings of this study are as follows. 1) After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. 2) In all three tissues, the activities of MCD and ACC are coordinately regulated by AMPK. 3) GPAT activity is diminished in liver and adipose tissue after exercise, and this too appears to be regulated by AMPK. 4) The net effect of these changes should be to increase the oxidation of fatty acids and to diminish their esterification.
Formal Description
Interaction-ID: 12764



increases_activity of