General Information:

Id: 492
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
article
Reference: Park H et al.(2002) Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J. Biol. Chem. 277 [PMID: 12065578]

Interaction Information:

Comment Thirty min after the completion of a treadmill run, MCD activity was increased approximately 2-fold, malonyl-CoA levels were reduced, and ACC and GPAT activities were diminished by 50% in muscle and liver.
Formal Description
Interaction-ID: 2341

environment

exercise

increases_activity of

gene/protein

MLYCD

in muscle, in liver, in adipose tissue
Comment Thirty min after the completion of a treadmill run, MCD activity was increased approximately 2-fold, malonyl-CoA levels were reduced, and ACC and GPAT activities were diminished by 50% in muscle and liver.
Formal Description
Interaction-ID: 2343

environment

exercise

decreases_quantity of

drug/chemical compound

Malonyl-CoA

in muscle, in liver, in adipose tissue
Comment Thirty min after the completion of a treadmill run, MCD activity was increased approximately 2-fold, malonyl-CoA levels were reduced, and ACC and GPAT activities were diminished by 50% in muscle and liver.
Formal Description
Interaction-ID: 2344

environment

exercise

decreases_activity of

gene/protein

ACAC

in muscle, in liver, in adipose tissue
Comment Thirty min after the completion of a treadmill run, MCD activity was increased approximately 2-fold, malonyl-CoA levels were reduced, and ACC and GPAT activities were diminished by 50% in muscle and liver.
Formal Description
Interaction-ID: 2345

environment

exercise

decreases_activity of

gene/protein

Mitochondrial GPAT

in liver, in adipose tissue
Comment The activities of both the alpha1 and alpha2 AMPK isoforms increased in response to exercise in both liver and muscle with predominantly alpha1-AMPK increasing in liver and alpha2-AMPK in muscle. In adipose tissue, in which it was not possible to immunopurify the individual AMPK catalytic alpha chain isoforms, total AMPK activity was increased by 509 %.
Formal Description
Interaction-ID: 2350

environment

exercise

increases_activity of

complex/PPI

AMPK

in muscle, in liver, in adipose tissue
Comment Mitochondrial GPAT activity in gastrocnemius muscle was not affected by exercise.
Formal Description
Interaction-ID: 2352

environment

exercise

NOT affects_activity of

gene/protein

Mitochondrial GPAT

in muscle
Comment Exercise did not affect microsomal GPAT activity in any of the tissues examined.
Formal Description
Interaction-ID: 2354

environment

exercise

NOT affects_activity of

gene/protein

Microsomal GPAT

in muscle, in liver, in adipose tissue
Comment The subcutaneous administration of AICAR (250 mg/kg of body weight) decreased the concentration of malonyl-CoA in epididymal fat from 14 nmol/g to 7.6 nmol/g. In addition, it caused alteration in the activities of ACC, MCD, and GPAT in the three tissues very similar to those observed 30 min after exercise.
Formal Description
Interaction-ID: 2363

drug/chemical compound

AICAR

decreases_quantity of

drug/chemical compound

Malonyl-CoA

in adipose tissue
Drugbank entries Show/Hide entries for AICAR
Comment The subcutaneous administration of AICAR (250 mg/kg of body weight) decreased the concentration of malonyl-CoA in epididymal fat from 14 nmol/g to 7.6 nmol/g. In addition, it caused alteration in the activities of ACC, MCD, and GPAT in the three tissues very similar to those observed 30 min after exercise.
Formal Description
Interaction-ID: 2371

drug/chemical compound

AICAR

decreases_activity of

gene/protein

ACAC

in muscle, in liver, in adipose tissue
Drugbank entries Show/Hide entries for AICAR
Comment The subcutaneous administration of AICAR (250 mg/kg of body weight) decreased the concentration of malonyl-CoA in epididymal fat from 14 nmol/g to 7.6 nmol/g. In addition, it caused alteration in the activities of ACC, MCD, and GPAT in the three tissues very similar to those observed 30 min after exercise.
Formal Description
Interaction-ID: 2372

drug/chemical compound

AICAR

increases_activity of

gene/protein

MLYCD

in muscle, in liver, in adipose tissue
Drugbank entries Show/Hide entries for AICAR
Comment The subcutaneous administration of AICAR (250 mg/kg of body weight) decreased the concentration of malonyl-CoA in epididymal fat from 14 nmol/g to 7.6 nmol/g. In addition, it caused alteration in the activities of ACC, MCD, and GPAT in the three tissues very similar to those observed 30 min after exercise.
Formal Description
Interaction-ID: 2373

drug/chemical compound

AICAR

decreases_activity of

gene/protein

GPAT

in adipose tissue
Drugbank entries Show/Hide entries for AICAR
Comment The increase in MCD activity in muscle was reversed in vitro by incubating immunoprecipitated enzyme from the exercised muscle with protein phosphatase 2A, and it was reproduced by incubating immunopurified MCD from resting muscle with purified AMPK.
Formal Description
Interaction-ID: 2375

complex/PPI

AMPK

increases_activity of

gene/protein

MLYCD

in muscle
Comment The principal findings of this study are as follows. 1) After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. 2) In all three tissues, the activities of MCD and ACC are coordinately regulated by AMPK. 3) GPAT activity is diminished in liver and adipose tissue after exercise, and this too appears to be regulated by AMPK. 4) The net effect of these changes should be to increase the oxidation of fatty acids and to diminish their esterification.
Formal Description
Interaction-ID: 2377

gene/protein

MLYCD

affects_quantity of

drug/chemical compound

Malonyl-CoA

in muscle, in liver, in adipose tissue
Comment The principal findings of this study are as follows. 1) After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. 2) In all three tissues, the activities of MCD and ACC are coordinately regulated by AMPK. 3) GPAT activity is diminished in liver and adipose tissue after exercise, and this too appears to be regulated by AMPK. 4) The net effect of these changes should be to increase the oxidation of fatty acids and to diminish their esterification.
Formal Description
Interaction-ID: 12762

gene/protein

ACAC

affects_quantity of

drug/chemical compound

Malonyl-CoA

in muscle, in liver, in adipose tissue
Comment The principal findings of this study are as follows. 1) After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. 2) In all three tissues, the activities of MCD and ACC are coordinately regulated by AMPK. 3) GPAT activity is diminished in liver and adipose tissue after exercise, and this too appears to be regulated by AMPK. 4) The net effect of these changes should be to increase the oxidation of fatty acids and to diminish their esterification.
Formal Description
Interaction-ID: 12763

complex/PPI

AMPK

affects_activity of

gene/protein

ACAC

in muscle, in liver, in adipose tissue
Comment The principal findings of this study are as follows. 1) After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. 2) In all three tissues, the activities of MCD and ACC are coordinately regulated by AMPK. 3) GPAT activity is diminished in liver and adipose tissue after exercise, and this too appears to be regulated by AMPK. 4) The net effect of these changes should be to increase the oxidation of fatty acids and to diminish their esterification.
Formal Description
Interaction-ID: 12764

environment

exercise

increases_activity of

Comment The principal findings of this study are as follows. 1) After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. 2) In all three tissues, the activities of MCD and ACC are coordinately regulated by AMPK. 3) GPAT activity is diminished in liver and adipose tissue after exercise, and this too appears to be regulated by AMPK. 4) The net effect of these changes should be to increase the oxidation of fatty acids and to diminish their esterification.
Formal Description
Interaction-ID: 12765

environment

exercise

decreases_activity of

Comment The principal findings of this study are as follows. 1) After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. 2) In all three tissues, the activities of MCD and ACC are coordinately regulated by AMPK. 3) GPAT activity is diminished in liver and adipose tissue after exercise, and this too appears to be regulated by AMPK. 4) The net effect of these changes should be to increase the oxidation of fatty acids and to diminish their esterification.
Formal Description
Interaction-ID: 12766

environment

exercise

decreases_activity of

gene/protein

GPAT

via AMPK