General Information:

Id: 4,908 (click here to show other Interactions for entry)
Diseases: Schizophrenia - [OMIM]
Reference: Yin J et al.(2014) miR-137: a new player in schizophrenia Int J Mol Sci 15: 3262-3271 [PMID: 24566148]

Interaction Information:

Comment The dopamine receptor D2 (DRD2) gene is a ZNF804A target gene, associated with the dopamine pathway. When the dopaminergic system in the mesolimbic pathway is hyperactive, the hyperactivation of the postsynaptic membrane D2 receptor can induce positive symptoms, such as hallucinations and delusions. Antipsychotic drugs include mainly DRD2 blockers, which can attenuate abnormal excitation to inhibit symptoms of schizophrenia.
Formal Description
Interaction-ID: 48602



affects_activity of

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