General Information:

Id: 4,908 (click here to show other Interactions for entry)
Diseases: Schizophrenia - [OMIM]
Mammalia
review
Reference: Yin J et al.(2014) miR-137: a new player in schizophrenia Int J Mol Sci 15: 3262-3271 [PMID: 24566148]

Interaction Information:

Comment The dopamine receptor D2 (DRD2) gene is a ZNF804A target gene, associated with the dopamine pathway. When the dopaminergic system in the mesolimbic pathwayis hyperactive, the hyperactivation of the postsynaptic membrane D2 receptor can induce positive symptoms, such as hallucinations and delusions [30]. Antipsychotic drugs include mainly DRD2 blockers, which can attenuate abnormal excitation to inhibit symptoms of schizophreni.
Formal Description
Interaction-ID: 48601

gene/protein

ZNF804A

affects_expression of

gene/protein

DRD2

Drugbank entries Show/Hide entries for DRD2
Comment The dopamine receptor D2 (DRD2) gene is a ZNF804A target gene, associated with the dopamine pathway. When the dopaminergic system in the mesolimbic pathway is hyperactive, the hyperactivation of the postsynaptic membrane D2 receptor can induce positive symptoms, such as hallucinations and delusions. Antipsychotic drugs include mainly DRD2 blockers, which can attenuate abnormal excitation to inhibit symptoms of schizophrenia.
Formal Description
Interaction-ID: 48602

gene/protein

DRD2

affects_activity of

Drugbank entries Show/Hide entries for DRD2