General Information:

Id: 4,908
Diseases: Schizophrenia - [OMIM]
Mammalia
review
Reference: Yin J et al.(2014) miR-137: a new player in schizophrenia Int J Mol Sci 15: 3262-3271 [PMID: 24566148]

Interaction Information:

Comment MiR-137 is expressed in neural stem cells (NSCs) and many regions of the brain, including the amygdala, hippocampus, orbital frontal cortex, nucleus accumbens, anterior cingulate cortex, dorsolateral prefrontal cortex, caudate nucleus, putamen, and thalamus. The highest miR-137 expression levels were observed in amygdala and the hippocampus, especially in adult brain region with active neurogenesis, the subgranular cell layer in the hippocampal dentate gyrus.
Formal Description
Interaction-ID: 48481

ncRNA/miRNA

mir-137

is_expressed_in

tissue/cell line

neural stem cell

Comment MiR-137 is expressed in neural stem cells (NSCs) and many regions of the brain, including the amygdala, hippocampus, orbital frontal cortex, nucleus accumbens, anterior cingulate cortex, dorsolateral prefrontal cortex, caudate nucleus, putamen, and thalamus. The highest miR-137 expression levels were observed in amygdala and the hippocampus, especially in adult brain region with active neurogenesis, the subgranular cell layer in the hippocampal dentate gyrus.
Formal Description
Interaction-ID: 48482

ncRNA/miRNA

mir-137

is_expressed_in

tissue/cell line

amygdala

Comment MiR-137 is expressed in neural stem cells (NSCs) and many regions of the brain, including the amygdala, hippocampus, orbital frontal cortex, nucleus accumbens, anterior cingulate cortex, dorsolateral prefrontal cortex, caudate nucleus, putamen, and thalamus. The highest miR-137 expression levels were observed in amygdala and the hippocampus, especially in adult brain region with active neurogenesis, the subgranular cell layer in the hippocampal dentate gyrus.
Formal Description
Interaction-ID: 48483

ncRNA/miRNA

mir-137

is_expressed_in

tissue/cell line

hippocampus

Comment MiR-137 is expressed in neural stem cells (NSCs) and many regions of the brain, including the amygdala, hippocampus, orbital frontal cortex, nucleus accumbens, anterior cingulate cortex, dorsolateral prefrontal cortex, caudate nucleus, putamen, and thalamus. The highest miR-137 expression levels were observed in amygdala and the hippocampus, especially in adult brain region with active neurogenesis, the subgranular cell layer in the hippocampal dentate gyrus.
Formal Description
Interaction-ID: 48484

ncRNA/miRNA

mir-137

is_expressed_in

tissue/cell line

orbital frontal cortex

Comment MiR-137 is expressed in neural stem cells (NSCs) and many regions of the brain, including the amygdala, hippocampus, orbital frontal cortex, nucleus accumbens, anterior cingulate cortex, dorsolateral prefrontal cortex, caudate nucleus, putamen, and thalamus. The highest miR-137 expression levels were observed in amygdala and the hippocampus, especially in adult brain region with active neurogenesis, the subgranular cell layer in the hippocampal dentate gyrus.
Formal Description
Interaction-ID: 48485

ncRNA/miRNA

mir-137

is_expressed_in

tissue/cell line

nucleus accumbens

Comment MiR-137 is expressed in neural stem cells (NSCs) and many regions of the brain, including the amygdala, hippocampus, orbital frontal cortex, nucleus accumbens, anterior cingulate cortex, dorsolateral prefrontal cortex, caudate nucleus, putamen, and thalamus. The highest miR-137 expression levels were observed in amygdala and the hippocampus, especially in adult brain region with active neurogenesis, the subgranular cell layer in the hippocampal dentate gyrus.
Formal Description
Interaction-ID: 48486

ncRNA/miRNA

mir-137

is_expressed_in

tissue/cell line

anterior cingulate cortex

Comment MiR-137 is expressed in neural stem cells (NSCs) and many regions of the brain, including the amygdala, hippocampus, orbital frontal cortex, nucleus accumbens, anterior cingulate cortex, dorsolateral prefrontal cortex, caudate nucleus, putamen, and thalamus. The highest miR-137 expression levels were observed in amygdala and the hippocampus, especially in adult brain region with active neurogenesis, the subgranular cell layer in the hippocampal dentate gyrus.
Formal Description
Interaction-ID: 48487

ncRNA/miRNA

mir-137

is_expressed_in

tissue/cell line

dorsolateral prefrontal cortex

Comment MiR-137 is expressed in neural stem cells (NSCs) and many regions of the brain, including the amygdala, hippocampus, orbital frontal cortex, nucleus accumbens, anterior cingulate cortex, dorsolateral prefrontal cortex, caudate nucleus, putamen, and thalamus. The highest miR-137 expression levels were observed in amygdala and the hippocampus, especially in adult brain region with active neurogenesis, the subgranular cell layer in the hippocampal dentate gyrus.
Formal Description
Interaction-ID: 48488

ncRNA/miRNA

mir-137

is_expressed_in

tissue/cell line

caudate nucleus

Comment MiR-137 is expressed in neural stem cells (NSCs) and many regions of the brain, including the amygdala, hippocampus, orbital frontal cortex, nucleus accumbens, anterior cingulate cortex, dorsolateral prefrontal cortex, caudate nucleus, putamen, and thalamus. The highest miR-137 expression levels were observed in amygdala and the hippocampus, especially in adult brain region with active neurogenesis, the subgranular cell layer in the hippocampal dentate gyrus.
Formal Description
Interaction-ID: 48489

ncRNA/miRNA

mir-137

is_expressed_in

tissue/cell line

caudate putamen

Comment MiR-137 is expressed in neural stem cells (NSCs) and many regions of the brain, including the amygdala, hippocampus, orbital frontal cortex, nucleus accumbens, anterior cingulate cortex, dorsolateral prefrontal cortex, caudate nucleus, putamen, and thalamus. The highest miR-137 expression levels were observed in amygdala and the hippocampus, especially in adult brain region with active neurogenesis, the subgranular cell layer in the hippocampal dentate gyrus.
Formal Description
Interaction-ID: 48490

ncRNA/miRNA

mir-137

is_expressed_in

tissue/cell line

thalamus

Comment Autopsy results on schizophrenia patients indicated that the miR-137 expression level in the dorsolateral prefrontal cortex was significantly decreased compared to that in the control group. This result also suggested a relationship between miR-137 and schizophrenia.
Formal Description
Interaction-ID: 48504

phenotype

decreased mir-137 expression

cooccurs with

disease

Schizophrenia

in the dorsolateral prefrontal cortex
Comment In embryonic NSCs, miR-137 expression is regulated by the nuclear receptor transcription factor TLX and the histone demethylase LSD1 (lysine specific demethylase 1).
Formal Description
Interaction-ID: 48543

gene/protein

NR2E1

decreases_expression of

ncRNA/miRNA

mir-137

in embryonic NSCs; TLX represses the expression of miR-137 by recruiting LSD1 to the genomic regions of miR-137.
Comment In embryonic NSCs, miR-137 expression is regulated by the nuclear receptor transcription factor TLX and the histone demethylase LSD1 (lysine specific demethylase 1). LSD1 is a target gene of miR-137, the inhibition of LSD1 by miR-137 promotes miR-137 expression accordingly. Therefore, miR-137 forms a negative feedback regulatory loop with LSD1 and TLX to ensure its expression is maintained at an appropriate level.
Formal Description
Interaction-ID: 48544

gene/protein

KDM1A

decreases_expression of

ncRNA/miRNA

mir-137

in embryonic NSCs; LSD1 is a target gene of miR-137; thus, miR-137 forms a negative feedback regulatory loop with LSD1 and TLX to ensure its expression is maintained at an appropriate level.
Comment TLX recruits its corepressor LSD1 to form a complex and then binds to a genomic region of miR-137 gene to inhibit the transcription of pre-miR-137.
Formal Description
Interaction-ID: 48545

gene/protein

NR2E1

interacts (colocalizes) with

gene/protein

KDM1A

to form a complex and then binds to a genomic region of miR-137 gene
Comment LSD1 is a target gene of miR-137, the inhibition of LSD1 by miR-137 promotes miR-137 expression accordingly. Therefore, miR-137 forms a negative feedback regulatory loop with LSD1 and TLX to ensure its expression is maintained at an appropriate level.
Formal Description
Interaction-ID: 48546

ncRNA/miRNA

mir-137

decreases_expression of

gene/protein

KDM1A

forming a negative feedback regulatory loop with LSD1 and TLX
Comment In aNSCs (adult neural stem cells), MeCP2 along with Sox2 mediates the epigenetic regulation of miR-137. One target of miR-137, Ezh2, is a histone H3 lysine 27 methyltransferase. The miR-137–mediated repression of Ezh2 feeds back to chromatin, resulting in a global decrease in histone H3 trimethyl lysine 27.
Formal Description
Interaction-ID: 48547

gene/protein

MECP2

interacts (colocalizes) with

gene/protein

SOX2

in adult NSCs
Comment In aNSCs (adult neural stem cells), MeCP2 along with Sox2 mediates the epigenetic regulation of miR-137. One target of miR-137, Ezh2, is a histone H3 lysine 27 methyltransferase. The miR-137–mediated repression of Ezh2 feeds back to chromatin, resulting in a global decrease in histone H3 trimethyl lysine 27.
Formal Description
Interaction-ID: 48551

gene/protein

MECP2

decreases_expression of

ncRNA/miRNA

mir-137

in adult NSCs; MeCP2 interacts with the transcription factor Sox2 to form a complex that binds to the promoter region of miR-137 and establishes an epigenetic state in the chromatin to inhibit miR-137 transcription.
Comment In aNSCs (adult neural stem cells), MeCP2 along with Sox2 mediates the epigenetic regulation of miR-137. One target of miR-137, Ezh2, is a histone H3 lysine 27 methyltransferase. The miR-137–mediated repression of Ezh2 feeds back to chromatin, resulting in a global decrease in histone H3 trimethyl lysine 27.
Formal Description
Interaction-ID: 48552

gene/protein

SOX2

decreases_expression of

ncRNA/miRNA

mir-137

in adult NSCs; MeCP2 interacts with the transcription factor Sox2 to form a complex that binds to the promoter region of miR-137 and establishes an epigenetic state in the chromatin to inhibit miR-137 transcription.
Comment In aNSCs (adult neural stem cells), MeCP2 along with Sox2 mediates the epigenetic regulation of miR-137. One target of miR-137, Ezh2, is a histone H3 lysine 27 methyltransferase. The miR-137–mediated repression of Ezh2 feeds back to chromatin, resulting in a global decrease in histone H3 trimethyl lysine 27.
Formal Description
Interaction-ID: 48553

ncRNA/miRNA

mir-137

decreases_expression of

gene/protein

EZH2

in adult NSCs; The miR-137–mediated repression of Ezh2 feeds back to chromatin, resulting in a global decrease in histone H3 trimethyl lysine 27.
Comment MiR-137 can inhibit the transcription of Mind bomb 1 (Mib-1) through the conserved target site located in the 3' untranslated region of Mib1 mRNA. MiR-137 targets Mib-1 to regulate neuronal maturation and dendritic morphogenesis, thus affecting the structure and function of neuron.
Formal Description
Interaction-ID: 48568

ncRNA/miRNA

mir-137

decreases_expression of

gene/protein

MIB1

through the conserved target site located in the 3' untranslated region of Mib1 mRNA;
Comment MiR-137 participates in the regulation of signal transduction between synapses and long-term potentiation (LTP) through the regulation of another target gene, cyclooxygenase-2 (COX-2).
Formal Description
Interaction-ID: 48571

ncRNA/miRNA

mir-137

affects_expression of

gene/protein

PTGS2

Drugbank entries Show/Hide entries for PTGS2
Comment Predicted miR-137 target genes that were associated with schizophrenia are listed.
Formal Description
Interaction-ID: 48575

ncRNA/miRNA

mir-137

affects_expression of

gene/protein

TCF4

a schizophrenia-associated gene
Comment Predicted miR-137 target genes that were associated with schizophrenia are listed.
Formal Description
Interaction-ID: 48583

ncRNA/miRNA

mir-137

affects_expression of

gene/protein

CACNA1C

a schizophrenia-associated gene
Drugbank entries Show/Hide entries for CACNA1C
Comment Predicted miR-137 target genes that were associated with schizophrenia are listed.
Formal Description
Interaction-ID: 48585

ncRNA/miRNA

mir-137

affects_expression of

gene/protein

CSMD1

a schizophrenia-associated gene
Comment Predicted miR-137 target genes that were associated with schizophrenia are listed.
Formal Description
Interaction-ID: 48587

ncRNA/miRNA

mir-137

affects_expression of

gene/protein

ZNF804A

a schizophrenia-associated gene
Comment Predicted miR-137 target genes that were associated with schizophrenia are listed.
Formal Description
Interaction-ID: 48588

ncRNA/miRNA

mir-137

affects_expression of

gene/protein

WBP1L

a schizophrenia-associated gene
Comment ZNF804A participates in dopamine signaling pathways, and its target gene, catechol-O-methyltransferase (COMT), can directly and selectively degrade dopamine in prefrontal cortex synapses through methylation.
Formal Description
Interaction-ID: 48590

gene/protein

ZNF804A

affects_expression of

gene/protein

COMT

Drugbank entries Show/Hide entries for COMT
Comment The dopamine receptor D2 (DRD2) gene is a ZNF804A target gene, associated with the dopamine pathway. When the dopaminergic system in the mesolimbic pathwayis hyperactive, the hyperactivation of the postsynaptic membrane D2 receptor can induce positive symptoms, such as hallucinations and delusions [30]. Antipsychotic drugs include mainly DRD2 blockers, which can attenuate abnormal excitation to inhibit symptoms of schizophreni.
Formal Description
Interaction-ID: 48601

gene/protein

ZNF804A

affects_expression of

gene/protein

DRD2

Drugbank entries Show/Hide entries for DRD2
Comment The dopamine receptor D2 (DRD2) gene is a ZNF804A target gene, associated with the dopamine pathway. When the dopaminergic system in the mesolimbic pathway is hyperactive, the hyperactivation of the postsynaptic membrane D2 receptor can induce positive symptoms, such as hallucinations and delusions. Antipsychotic drugs include mainly DRD2 blockers, which can attenuate abnormal excitation to inhibit symptoms of schizophrenia.
Formal Description
Interaction-ID: 48602

gene/protein

DRD2

affects_activity of

Drugbank entries Show/Hide entries for DRD2
Comment There exists no association between the following single nucleotide polymorphism (SNP) loci of miR-137 and schizophrenia: (rs4634961, rs9324387, rs2391905, rs4950117, rs1938568, rs4950101, rs2802535, rs2660304, g.98511534 G > C, g.98511769 G > T, and g.98511780 T > C).
Formal Description
Interaction-ID: 48670

NOT affects_activity of

disease

Schizophrenia

Comment There exists no association between the following single nucleotide polymorphism (SNP) loci of miR-137 and schizophrenia: (rs4634961, rs9324387, rs2391905, rs4950117, rs1938568, rs4950101, rs2802535, rs2660304, g.98511534 G > C, g.98511769 G > T, and g.98511780 T > C).
Formal Description
Interaction-ID: 48671

NOT affects_activity of

disease

Schizophrenia

Comment There exists no association between the following single nucleotide polymorphism (SNP) loci of miR-137 and schizophrenia: (rs4634961, rs9324387, rs2391905, rs4950117, rs1938568, rs4950101, rs2802535, rs2660304, g.98511534 G > C, g.98511769 G > T, and g.98511780 T > C).
Formal Description
Interaction-ID: 48672

NOT affects_activity of

disease

Schizophrenia

Comment There exists no association between the following single nucleotide polymorphism (SNP) loci of miR-137 and schizophrenia: (rs4634961, rs9324387, rs2391905, rs4950117, rs1938568, rs4950101, rs2802535, rs2660304, g.98511534 G > C, g.98511769 G > T, and g.98511780 T > C).
Formal Description
Interaction-ID: 48673

NOT affects_activity of

disease

Schizophrenia

Comment There exists no association between the following single nucleotide polymorphism (SNP) loci of miR-137 and schizophrenia: (rs4634961, rs9324387, rs2391905, rs4950117, rs1938568, rs4950101, rs2802535, rs2660304, g.98511534 G > C, g.98511769 G > T, and g.98511780 T > C).
Formal Description
Interaction-ID: 48674

NOT affects_activity of

disease

Schizophrenia

Comment There exists no association between the following single nucleotide polymorphism (SNP) loci of miR-137 and schizophrenia: (rs4634961, rs9324387, rs2391905, rs4950117, rs1938568, rs4950101, rs2802535, rs2660304, g.98511534 G > C, g.98511769 G > T, and g.98511780 T > C).
Formal Description
Interaction-ID: 48675

NOT affects_activity of

disease

Schizophrenia

Comment There exists no association between the following single nucleotide polymorphism (SNP) loci of miR-137 and schizophrenia: (rs4634961, rs9324387, rs2391905, rs4950117, rs1938568, rs4950101, rs2802535, rs2660304, g.98511534 G > C, g.98511769 G > T, and g.98511780 T > C).
Formal Description
Interaction-ID: 48676

NOT affects_activity of

disease

Schizophrenia

Comment There exists no association between the following single nucleotide polymorphism (SNP) loci of miR-137 and schizophrenia: (rs4634961, rs9324387, rs2391905, rs4950117, rs1938568, rs4950101, rs2802535, rs2660304, g.98511534 G > C, g.98511769 G > T, and g.98511780 T > C).
Formal Description
Interaction-ID: 48677

NOT affects_activity of

disease

Schizophrenia

Comment There exists no association between the following single nucleotide polymorphism (SNP) loci of miR-137 and schizophrenia: (rs4634961, rs9324387, rs2391905, rs4950117, rs1938568, rs4950101, rs2802535, rs2660304, g.98511534 G > C, g.98511769 G > T, and g.98511780 T > C).
Formal Description
Interaction-ID: 48678

gene/protein mutant

MIR137-g.98511534

NOT affects_activity of

disease

Schizophrenia

Comment There exists no association between the following single nucleotide polymorphism (SNP) loci of miR-137 and schizophrenia: (rs4634961, rs9324387, rs2391905, rs4950117, rs1938568, rs4950101, rs2802535, rs2660304, g.98511534 G > C, g.98511769 G > T, and g.98511780 T > C).
Formal Description
Interaction-ID: 48679

gene/protein mutant

MIR137-g.98511769

NOT affects_activity of

disease

Schizophrenia

Comment There exists no association between the following single nucleotide polymorphism (SNP) loci of miR-137 and schizophrenia: (rs4634961, rs9324387, rs2391905, rs4950117, rs1938568, rs4950101, rs2802535, rs2660304, g.98511534 G > C, g.98511769 G > T, and g.98511780 T > C).
Formal Description
Interaction-ID: 48680

gene/protein mutant

MIR137-g.98511780

NOT affects_activity of

disease

Schizophrenia

Comment The rs1625579 genotype showed a significant correlation with Chinese Han people with schizophrenia compared to the control group.
Formal Description
Interaction-ID: 48681

increases_activity of

disease

Schizophrenia

in Han Chinese