General Information:

Id: 489 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000567 HeLa cell; BTO:0000793 SH-SY5Y cell
article
Reference: Michiorri S et al.(2010) The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy Cell Death Differ. 17: 962-974 [PMID: 20057503]

Interaction Information:

Comment PINK1, as well as the pathogenic mutant PINK1-G309D (with defective kinase activity but unaltered Beclin1 binding), but not its pathogenic mutant PINK1-W437X (with impaired ability to bind Beclin1), enhances autophagy.
Formal Description
Interaction-ID: 2314

gene/protein mutant

PINK1-p.W437X

NOT increases_activity of

process

autophagy