General Information:

Id: 488 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
article
Reference: Ye JM et al.(2002) Prior thiazolidinedione treatment preserves insulin sensitivity in normal rats during acute fatty acid elevation: role of the liver. Endocrinology 143: 4527-4535 [PMID: 12446579]

Interaction Information:

Comment Pioglitazone treatment reduced plasma levels of triglycerides, FFAs, leptin, and insulin by 23%, 21%, 44%, and 29%, respectively, but did not alter glucose concentration. There was a slight (17%) increase in muscle triglyceride content, whereas no differences were found in glycogen and other lipid metabolites in muscle or liver among the groups.
Formal Description
Interaction-ID: 2317

drug/chemical compound

Pioglitazone

decreases_quantity of

gene/protein

LEP

in blood
Drugbank entries Show/Hide entries for Pioglitazone