General Information:

Id: 488 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
Reference: Ye JM et al.(2002) Prior thiazolidinedione treatment preserves insulin sensitivity in normal rats during acute fatty acid elevation: role of the liver. Endocrinology 143: 4527-4535 [PMID: 12446579]

Interaction Information:

Comment Thiazolidinediones can protect against lipid-induced insulin resistance with a significant component (mainly liver) of the protective effect not requiring lipid lowering. This may be related to chronic elevation of adiponectin by thiazolidinediones.
Formal Description
Interaction-ID: 2305

drug/chemical compound


affects_activity of


Insulin resistance