General Information:

Id: 4,824 (click here to show other Interactions for entry)
Diseases: Neurological
Mus musculus
Reference: Beutler LR et al.(2011) Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization Proc. Natl. Acad. Sci. U.S.A. 108: 4206-4211 [PMID: 21368124]

Interaction Information:

Comment D1R- and D2R-expressing neurons have opposing roles in mediating sensitization to AMPH. Specifically, D1R neuron activity promotes whereas D2R neuron activity inhibits AMPH sensitization.
Formal Description
Interaction-ID: 47682



decreases_activity of


neuron sensitization

to AMPH (amphetamine)
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