General Information:

Id: 4,824
Diseases: Neurological
Mus musculus
article
Reference: Beutler LR et al.(2011) Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization Proc. Natl. Acad. Sci. U.S.A. 108: 4206-4211 [PMID: 21368124]

Interaction Information:

Comment D1R- and D2R-expressing neurons have opposing roles in mediating sensitization to AMPH. Specifically, D1R neuron activity promotes whereas D2R neuron activity inhibits AMPH sensitization.
Formal Description
Interaction-ID: 47643

gene/protein

DRD2

affects_activity of

tissue/cell line

neuron

(of D2R-expressing neurons)
Drugbank entries Show/Hide entries for DRD2
Comment D1R- and D2R-expressing neurons have opposing roles in mediating sensitization to AMPH. Specifically, D1R neuron activity promotes whereas D2R neuron activity inhibits AMPH sensitization.
Formal Description
Interaction-ID: 47681

gene/protein

DRD1

affects_activity of

tissue/cell line

neuron

(of D1R-expressing neurons)
Drugbank entries Show/Hide entries for DRD1
Comment D1R- and D2R-expressing neurons have opposing roles in mediating sensitization to AMPH. Specifically, D1R neuron activity promotes whereas D2R neuron activity inhibits AMPH sensitization.
Formal Description
Interaction-ID: 47682

gene/protein

DRD2

decreases_activity of

process

neuron sensitization

to AMPH (amphetamine)
Drugbank entries Show/Hide entries for DRD2
Comment D1R- and D2R-expressing neurons have opposing roles in mediating sensitization to AMPH. Specifically, D1R neuron activity promotes whereas D2R neuron activity inhibits AMPH sensitization.
Formal Description
Interaction-ID: 47683

gene/protein

DRD1

increases_activity of

process

neuron sensitization

to AMPH (amphetamine)
Drugbank entries Show/Hide entries for DRD1
Comment D1R- and D2R-expressing neurons have opposing roles in mediating sensitization to AMPH. Specifically, D1R neuron activity promotes whereas D2R neuron activity inhibits AMPH sensitization.
Formal Description
Interaction-ID: 47686

gene/protein

DRD2

decreases_activity of

of D2R-expressing neurons
Drugbank entries Show/Hide entries for DRD2
Comment D1R- and D2R-expressing neurons have opposing roles in mediating sensitization to AMPH. Specifically, D1R neuron activity promotes whereas D2R neuron activity inhibits AMPH sensitization.
Formal Description
Interaction-ID: 47687

gene/protein

DRD1

increases_activity of

of D1R-expressing neurons
Drugbank entries Show/Hide entries for DRD1
Comment Unbalanced loss of NMDAR signaling in D1R MSNs alone prevents AMPH sensitization, whereas a balanced loss of NMDARs from both D1R and dopamine D2 receptor-expressing (D2R) MSNs is permissive for sensitization.
Formal Description
Interaction-ID: 47688

complex/PPI

NMDA receptor complex

affects_activity of

process

neuron sensitization

in D1R and D2R MSNs (medium spiny neurons)
Comment Unbalanced loss of NMDAR signaling in D1R MSNs alone prevents AMPH sensitization, whereas a balanced loss of NMDARs from both D1R and dopamine D2 receptor-expressing (D2R) MSNs is permissive for sensitization.
Formal Description
Interaction-ID: 47692

complex/PPI

NMDA receptor complex

affects_activity of

in D1R and D2R MSNs (medium spiny neurons)
Comment MSNs express the dopamine D1 receptor (D1R) and dopamine D2 receptors (D2R).
Formal Description
Interaction-ID: 47694

tissue/cell line

medium spiny neuron

increases_expression of

gene/protein

DRD2

Drugbank entries Show/Hide entries for DRD2
Comment MSNs express the dopamine D1 receptor (D1R) and dopamine D2 receptors (D2R).
Formal Description
Interaction-ID: 47695

tissue/cell line

medium spiny neuron

increases_expression of

gene/protein

DRD1

Drugbank entries Show/Hide entries for DRD1
Comment The neuron sensitization is part of response to amphetamine.
Formal Description
Interaction-ID: 47696

process

neuron sensitization

affects_activity of