General Information:

Id: 479 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0001009 PC-12 cell
Reference: Cuervo AM et al.(2004) Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305: 1292-1295 [PMID: 15333840]

Interaction Information:

Comment Wild-type alpha-synuclein is internalized and degraded in lysosomes by CMA, but the pathogenic alpha-synuclein mutations are poorly degraded by CMA despite a high affinity for the CMA receptor LAMPB.
Formal Description
Interaction-ID: 2268



NOT decreases_quantity of

gene/protein mutant