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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	479 (click here to show other Interactions for entry)
Diseases:	Parkinson disease
Organism:	Homo sapiens
Tissue/Cell line:	BTO:0001009 PC-12 cell
Publication type:	article
Reference:	Cuervo AM et al.(2004) Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305: 1292-1295 [PMID: 15333840]

Interaction Information:

Comment	Wild-type alpha-synuclein is internalized and degraded in lysosomes by CMA, but the pathogenic alpha-synuclein mutations are poorly degraded by CMA despite a high affinity for the CMA receptor LAMPB.
Formal Description Interaction-ID: 2268	process autophagy NOT decreases_quantity of gene/protein mutant SNCA-p.A30P

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