General Information:

Id: 479 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0001009 PC-12 cell
article
Reference: Cuervo AM et al.(2004) Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305: 1292-1295 [PMID: 15333840]

Interaction Information:

Comment In PC-12 cells serum removal activates both macroautophagy and chaperone-mediated autophagy (CMA).
Formal Description
Interaction-ID: 2249

increases_activity of

process

macroautophagy

Comment In PC-12 cells serum removal activates both macroautophagy and chaperone-mediated autophagy (CMA).
Formal Description
Interaction-ID: 2250

increases_activity of

process

autophagy

Comment Wild-type alpha-synuclein is internalized and degraded in lysosomes by CMA.
Formal Description
Interaction-ID: 2257

process

autophagy

decreases_quantity of

gene/protein

SNCA

Comment Both A30P and A53T mutant alpha-synucleins bound intact lysosomes more strongly than did the wild-type protein, but the mutants were poorly internalized, thus impairing the degradation of other CMA substrates.
Formal Description
Interaction-ID: 2266

gene/protein mutant

SNCA-p.A30P

decreases_activity of

process

autophagy

Comment Both A30P and A53T mutant alpha-synucleins bound intact lysosomes more strongly than did the wild-type protein, but the mutants were poorly internalized, thus impairing the degradation of other CMA substrates.
Formal Description
Interaction-ID: 2267

gene/protein mutant

SNCA-p.A53T

decreases_activity of

process

autophagy

Comment Wild-type alpha-synuclein is internalized and degraded in lysosomes by CMA, but the pathogenic alpha-synuclein mutations are poorly degraded by CMA despite a high affinity for the CMA receptor LAMPB.
Formal Description
Interaction-ID: 2268

process

autophagy

NOT decreases_quantity of

gene/protein mutant

SNCA-p.A30P

Comment Wild-type alpha-synuclein is internalized and degraded in lysosomes by CMA, but the pathogenic alpha-synuclein mutations are poorly degraded by CMA despite a high affinity for the CMA receptor LAMPB.
Formal Description
Interaction-ID: 2269

process

autophagy

NOT decreases_quantity of

gene/protein mutant

SNCA-p.A53T