General Information:

Id: 4,792
Diseases: Neurological
Obesity - [OMIM]
Homo sapiens
article
Reference: Carpenter CL et al.(2013) Association of dopamine D2 receptor and leptin receptor genes with clinically severe obesity Obesity (Silver Spring) 21: E467-E473 [PMID: 23670889]

Interaction Information:

Comment The DRD2 TaqI A1 allele was significantly associated with BMI (P0.04), while LEPR Lys109Arg and OPRM1 A118G variants were not. Genes associated with addictive behavior and appetite control may therefore, in combination, markedly influence development of clinically severe obesity.
Formal Description
Interaction-ID: 47397

gene/protein mutant

DRD2 (TaqI A1 allele)

increases_activity of

Participants were mostly female (74%) and Caucasian (79%), with an average age of 53 years old.
Comment A significant interaction (P0.04) between DRD2 and LEPR, and a marginally significant interaction (P0.06) between DRD2 and OPRM1 was observed. Genes associated with addictive behavior and appetite control may therefore, in combination, markedly influence development of clinically severe obesity.
Formal Description
Interaction-ID: 47409

gene/protein

DRD2

interacts (colocalizes) with

gene/protein

LEPR

a significant interaction (P0.04)
Drugbank entries Show/Hide entries for DRD2
Comment A significant interaction (P0.04) between DRD2 and LEPR, and a marginally significant interaction (P0.06) between DRD2 and OPRM1 was observed. Genes associated with addictive behavior and appetite control may therefore, in combination, markedly influence development of clinically severe obesity.
Formal Description
Interaction-ID: 47411

gene/protein

DRD2

interacts (colocalizes) with

gene/protein

OPRM1

a marginally significant interaction (P0.06)
Drugbank entries Show/Hide entries for DRD2 or OPRM1