General Information:

Id: 477 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Rattus norvegicus
BTO:0000138 midbrain
article
Reference: Cuervo AM et al.(2004) Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305: 1292-1295 [PMID: 15333840]

Interaction Information:

Comment In contrast to the relatively small effect of epoxomicin, a selective proteasome inhibitor, on the half-life of alpha-synuclein, ammonium chloride, which inhibits lysosomal proteolysis independently of the form of autophagy that delivers substrates to lysosomes, strongly inhibited alpha-synuclein degradation.
Formal Description
Interaction-ID: 2239

drug/chemical compound

Ammonium chloride

decreases_activity of

process

autophagy