CIDeRGeneral Information:
| Id: | 477 (click here to show other Interactions for entry) |
| Diseases: |
Parkinson disease
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| Rattus norvegicus | |
| BTO:0000138 midbrain | |
| article | |
| Reference: | Cuervo AM et al.(2004) Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305: 1292-1295 [PMID: 15333840] |
Interaction Information:
| Comment | In contrast to the relatively small effect of epoxomicin, a selective proteasome inhibitor, on the half-life of alpha-synuclein, ammonium chloride, which inhibits lysosomal proteolysis independently of the form of autophagy that delivers substrates to lysosomes, strongly inhibited alpha-synuclein degradation. |
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Formal Description Interaction-ID: 2239 |
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