General Information:

Id: 4,776 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Reference: Kruit JK et al.(2012) Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired beta-cell function Diabetes 61: 659-664 [PMID: 22315310]

Interaction Information:

Comment To determine whether ABCA1 and ABCG1 have complementary roles in beta-cells, mice lacking ABCG1 and beta-cell ABCA1 were generated. Glucose-stimulated insulin secretion was decreased and sterol accumulation increased in islets lacking both transporters compared with those isolated from knockout mice with each gene alone.
Formal Description
Interaction-ID: 47269



affects_activity of

in pancreas
Drugbank entries Show/Hide entries for ABCA1