CIDeRGeneral Information:
| Id: | 4,776 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| article | |
| Reference: | Kruit JK et al.(2012) Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired beta-cell function Diabetes 61: 659-664 [PMID: 22315310] |
Interaction Information:
| Comment | To determine whether ABCA1 and ABCG1 have complementary roles in beta-cells, mice lacking ABCG1 and beta-cell ABCA1 were generated. Glucose-stimulated insulin secretion was decreased and sterol accumulation increased in islets lacking both transporters compared with those isolated from knockout mice with each gene alone. |
|
Formal Description Interaction-ID: 47269 |
gene/protein affects_activity of |
| Drugbank entries | Show/Hide entries for ABCA1 |