General Information:
Id: | 475 (click here to show other Interactions for entry) |
Diseases: |
Parkinson disease
|
Homo sapiens | |
BTO:0000138 midbrain; BTO:0000793 SH-SY5Y cell | |
article | |
Reference: | Zhu JH et al.(2007) Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death Am. J. Pathol. 170: 75-86 [PMID: 17200184] |
Interaction Information:
Comment | Knockdown of LC3 with siRNA showed significant protection of cells from MPP+-induced toxicity. Moreover, siRNA knockdown of Atg5 and Atg7, two other proteins involved in membrane conjugation necessary for initiating autophagy, also showed significant protection from cell death. |
Formal Description Interaction-ID: 2219 |
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