General Information:

Id: 475 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000138 midbrain; BTO:0000793 SH-SY5Y cell
article
Reference: Zhu JH et al.(2007) Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death Am. J. Pathol. 170: 75-86 [PMID: 17200184]

Interaction Information:

Comment Knockdown of LC3 with siRNA showed significant protection of cells from MPP+-induced toxicity. Moreover, siRNA knockdown of Atg5 and Atg7, two other proteins involved in membrane conjugation necessary for initiating autophagy, also showed significant protection from cell death.
Formal Description
Interaction-ID: 2219

gene/protein

ATG7

affects_activity of

process

neuron death

if cell death has been induced by MPP