General Information:

Id: 475 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000138 midbrain; BTO:0000793 SH-SY5Y cell
article
Reference: Zhu JH et al.(2007) Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death Am. J. Pathol. 170: 75-86 [PMID: 17200184]

Interaction Information:

Comment MEK inhibitors, like UO126, that reduce MPP+-induced autophagic vesicles, conferred significant protection from MPP+ toxicity. As observed in SH-SY5Y cells, MEK inhibition conferred protection from MPP+ in primary midbrain TH neurons.
Formal Description
Interaction-ID: 2215

drug/chemical compound

U0126

decreases_activity of

process

neuron death

if cell death has been induced by MPP