General Information:

Id: 475 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000138 midbrain; BTO:0000793 SH-SY5Y cell
article
Reference: Zhu JH et al.(2007) Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death Am. J. Pathol. 170: 75-86 [PMID: 17200184]

Interaction Information:

Comment Inhibitors of the upstream ERK kinase MEK, like UO126, effectively suppressed the autophagic response to MPP+ injury.
Formal Description
Interaction-ID: 2213

drug/chemical compound

U0126

decreases_activity of

process

autophagy

if autophagy has been induced by MPP treatment