General Information:

Id: 475 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000138 midbrain; BTO:0000793 SH-SY5Y cell
article
Reference: Zhu JH et al.(2007) Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death Am. J. Pathol. 170: 75-86 [PMID: 17200184]

Interaction Information:

Comment MPP+-treatment elicit significantly increased levels of the membrane-bound LC3 form. LC3 conjugation to the autophagic vesicle membrane is required for initiation of autophagy.
Formal Description
Interaction-ID: 2208

gene/protein

MAP1LC3A

affects_activity of

process

autophagy

Comment MPP+-treatment induces autophagic mitochondrial degradation. MPP+ elicited the appearance of granular LC3 staining in TH neurons, indicative of autophagy.
Formal Description
Interaction-ID: 2210

increases_activity of

process

macroautophagy

Comment Beclin1 associates with the class III PI3K to induce autophagy. Knockdown of Beclin 1 expression using RNA interference failed to inhibit MPP+-induced autophagy.
Formal Description
Interaction-ID: 2211

gene/protein

BECN1

increases_activity of

process

autophagy

Comment Inhibitors of the upstream ERK kinase MEK, like UO126, effectively suppressed the autophagic response to MPP+ injury.
Formal Description
Interaction-ID: 2213

drug/chemical compound

U0126

decreases_activity of

process

autophagy

if autophagy has been induced by MPP treatment