General Information:

Id: 474 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1G93A transgenic mouse, transfected with human SOD1G93A
BTO:0001279 spinal cord
article
Reference: Fornai F et al.(2008) Lithium delays progression of amyotrophic lateral sclerosis Proc. Natl. Acad. Sci. U.S.A. 105: 2052-2057 [PMID: 18250315]

Interaction Information:

Comment The autophagy inhibitor 3-MA (3-Methyladenine) increased G93A motor neuron (MN) death by 58% compared with NT G93A MN and by 51% compared with lithium-treated G93A MN. 3-MA administration 2h before lithium treatment, the latter could no longer counteract the effects of 3-MA, confirming that lithium neuroprotection occurs, at least partially, through an autophagic route.
Formal Description
Interaction-ID: 2237

drug/chemical compound

Lithium

decreases_activity of

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