General Information:
Id: | 474 |
Diseases: |
Amyotrophic lateral sclerosis
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Mus musculus | |
SOD1G93A transgenic mouse, transfected with human SOD1G93A | |
BTO:0001279 spinal cord | |
article | |
Reference: | Fornai F et al.(2008) Lithium delays progression of amyotrophic lateral sclerosis Proc. Natl. Acad. Sci. U.S.A. 105: 2052-2057 [PMID: 18250315] |
Interaction Information:
Comment | The treatment of G93A ALS mice with lithium delayed disease onset and duration and augmented the life span. |
Formal Description Interaction-ID: 2203 |
drug/chemical compound decreases_activity of disease Amyotrophic lateral sclerosis |
Drugbank entries | Show/Hide entries for Lithium |
Comment | Neurons within lamina VII of G93A mice were severely decreased. Lamina VII contains a larger number of interneurons, defined as Renshaw cells. Lithium administration in G93A mice increased the number of neurons, counted in lamina VII. |
Formal Description Interaction-ID: 2204 |
drug/chemical compound increases_quantity of tissue/cell line |
Drugbank entries | Show/Hide entries for Lithium |
Comment | Lithium administration in G93A mice reduced ubiquitin, and SOD1 aggregates in motor neurons. SOD1 accumulation was markedly cleared. |
Formal Description Interaction-ID: 2209 |
drug/chemical compound decreases_quantity of phenotype SOD1 protein aggregates |
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Comment | Lithium decreased vacuolization and normalized mitochondrial size. Lithium increased the number of normal mitochondria in both WT and G93A mice. |
Formal Description Interaction-ID: 2226 |
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Comment | Lithium administration increased the number of autophagic vacuoles as confirmed by autophagy markers, such as beclin or the microtubule-associated protein 1 light chain 3 (LC3). |
Formal Description Interaction-ID: 2232 |
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Drugbank entries | Show/Hide entries for Lithium |
Comment | Induction of autophagy by lithium was matched by increased expression of PTEN (the phosphatase acting on PIP3) and a marked reduction in the SER473 phosphorylation of Akt. |
Formal Description Interaction-ID: 2233 |
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Comment | The autophagy inhibitor 3-MA (3-Methyladenine) increased G93A motor neuron (MN) death by 58% compared with NT G93A MN and by 51% compared with lithium-treated G93A MN. 3-MA administration 2h before lithium treatment, the latter could no longer counteract the effects of 3-MA, confirming that lithium neuroprotection occurs, at least partially, through an autophagic route. |
Formal Description Interaction-ID: 2235 |
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Drugbank entries | Show/Hide entries for 3-Methyladenine |
Comment | The autophagy inhibitor 3-MA (3-Methyladenine) increased G93A motor neuron (MN) death by 58% compared with NT G93A MN and by 51% compared with lithium-treated G93A MN. 3-MA administration 2h before lithium treatment, the latter could no longer counteract the effects of 3-MA, confirming that lithium neuroprotection occurs, at least partially, through an autophagic route. |
Formal Description Interaction-ID: 2237 |
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Drugbank entries | Show/Hide entries for Lithium |