General Information:

Id: 471 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Charcot-Marie-Tooth disease, type 4J - [OMIM]
Mus musculus
mutant ingls (Vac14-L156R)
BTO:0000142 brain
article
Reference: Ferguson CJ et al.(2009) Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2 Hum. Mol. Genet. 18: 4868-4878 [PMID: 19793721]

Interaction Information:

Comment The accumulation and cellular location of autophagy markers in the ingls mutant closely resembles those of Fig4 (-/-) mice, supporting the view that the deficiency of phosphatidylinositide PI(3,5)P2 is responsible for defective autophagy and neurodegeneration in both mutants.
Formal Description
Interaction-ID: 2165

drug/chemical compound

Phosphatidylinositol-3,5-bisphosphate

affects_activity of

process

autophagy