General Information:

Id: 4,717
Diseases: Cardiovascular disease
Rattus norvegicus
endothelial progenitor cell (EPC): CD133+, VEGFR2+
article/cited
Reference: Chen J et al.(2012) C-reactive protein down-regulates endothelial nitric oxide synthase expression and promotes apoptosis in endothelial progenitor cells through receptor for advanced glycation end-products Gene 496: 128-135 [PMID: 22301267]

Interaction Information:

Comment C-reactive protein (CRP) is a well-known marker of inflammation. CRP has been shown to predict cardiovascular events. (cited information)
Formal Description
Interaction-ID: 46736

disease

Cardiovascular disease

increases_quantity of

gene/protein

CRP

Drugbank entries Show/Hide entries for CRP
Comment Nitric oxide derived from eNOS promotes arterial vasodilatation and inhibits smooth muscle cell proliferation, LDL oxidation, platelet adhesion and aggregation, and monocyte adhesion to the endothelium. (cited information)
Formal Description
Interaction-ID: 46737

drug/chemical compound

NO

increases_activity of

process

vasodilation

Comment Nitric oxide derived from eNOS promotes arterial vasodilatation and inhibits smooth muscle cell proliferation, LDL oxidation, platelet adhesion and aggregation, and monocyte adhesion to the endothelium. (cited information)
Formal Description
Interaction-ID: 46739

drug/chemical compound

NO

decreases_activity of

Comment Nitric oxide derived from eNOS promotes arterial vasodilatation and inhibits smooth muscle cell proliferation, LDL oxidation, platelet adhesion and aggregation, and monocyte adhesion to the endothelium. (cited information)
Formal Description
Interaction-ID: 46740

drug/chemical compound

NO

decreases_activity of

Comment Nitric oxide derived from eNOS promotes arterial vasodilatation and inhibits smooth muscle cell proliferation, LDL oxidation, platelet adhesion and aggregation, and monocyte adhesion to the endothelium. (cited information)
Formal Description
Interaction-ID: 46741

drug/chemical compound

NO

decreases_activity of

Comment The mRNA level of the multi-ligand receptor RAGE (AGER) significantly increases after treatment with CRP in endothelial progenitor cells. Activated RAGE leads to oxidative stress and propagation of inflammatory responses.
Formal Description
Interaction-ID: 46743

gene/protein

CRP

increases_expression of

gene/protein

AGER

Drugbank entries Show/Hide entries for CRP
Comment The mRNA level of the multi-ligand receptor RAGE (AGER) significantly increases after treatment with CRP in endothelial progenitor cells. Activated RAGE leads to oxidative stress and propagation of inflammatory responses. (cited information)
Formal Description
Interaction-ID: 46745

gene/protein

AGER

increases_activity of

Comment Both, the mRNA and protein level of endothelial NO synthase (eNOS) significantly decreases after treatment with CRP in endothelial progenitor cells. Down-regulation of RAGE (AGER) expression can obstruct this effect.
Formal Description
Interaction-ID: 46746

gene/protein

CRP

decreases_expression of

gene/protein

NOS3

by increasing the expression of RAGE
Drugbank entries Show/Hide entries for CRP or NOS3
Comment Both, the mRNA and protein level of endothelial NO synthase (eNOS) significantly decreases after treatment with CRP in endothelial progenitor cells. Down-regulation of RAGE (AGER) expression can obstruct this effect.
Formal Description
Interaction-ID: 46747

gene/protein

CRP

decreases_quantity of

gene/protein

NOS3

by increasing the expression of RAGE
Drugbank entries Show/Hide entries for CRP or NOS3
Comment Migration of endothelial progenitor cells was significantly reduced after CRP treatment.
Formal Description
Interaction-ID: 46748

gene/protein

CRP

decreases_activity of

process

cell migration

Drugbank entries Show/Hide entries for CRP
Comment Adhesion of endothelial progenitor cells was significantly reduced after CRP treatment.
Formal Description
Interaction-ID: 46749

gene/protein

CRP

decreases_activity of

process

cell adhesion

Drugbank entries Show/Hide entries for CRP
Comment Proliferation of endothelial progenitor cells was significantly reduced after CRP treatment.
Formal Description
Interaction-ID: 46750

gene/protein

CRP

decreases_activity of

Drugbank entries Show/Hide entries for CRP
Comment CRP induces apoptosis in endothelial progenitor cells.
Formal Description
Interaction-ID: 46751

gene/protein

CRP

increases_activity of

Drugbank entries Show/Hide entries for CRP
Comment CRP leads to the generation of ROS in endothelial progenitor cells. (cited information)
Formal Description
Interaction-ID: 46753

gene/protein

CRP

increases_quantity of

drug/chemical compound

Reactive oxygen species

in endothelial cells
Drugbank entries Show/Hide entries for CRP
Comment Both, the mRNA and protein level of endothelial NO synthase (eNOS) significantly decreases after treatment with CRP in endothelial progenitor cells. Down-regulation of RAGE (AGER) expression can obstruct this effect.
Formal Description
Interaction-ID: 46755

gene/protein

AGER

decreases_expression of

gene/protein

NOS3

by increasing the ROS level
Drugbank entries Show/Hide entries for NOS3
Comment Both, the mRNA and protein level of endothelial NO synthase (eNOS) significantly decreases after treatment with CRP in endothelial progenitor cells. Down-regulation of RAGE (AGER) expression can obstruct this effect.
Formal Description
Interaction-ID: 46756

gene/protein

AGER

decreases_quantity of

gene/protein

NOS3

by increasing the ROS level
Drugbank entries Show/Hide entries for NOS3
Comment The mRNA level of the multi-ligand receptor RAGE (AGER) significantly increases after treatment with CRP in endothelial progenitor cells. Activated RAGE leads to oxidative stress and propagation of inflammatory responses. (cited information)
Formal Description
Interaction-ID: 46757

gene/protein

AGER

increases_quantity of

drug/chemical compound

Reactive oxygen species