General Information:

Id: 46 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Rattus norvegicus
BTO:0000991 pancreatic islet
article
Reference: Manna P et al.(2009) Protective role of arjunolic acid in response to streptozotocin-induced type-I diabetes via the mitochondrial dependent and independent pathways. Toxicology 257: 53-63 [PMID: 19133311]

Interaction Information:

Comment STZ (Streptozotocin) intoxication increased the levels of serum TNF-alpha and NO under hyperglycemic condition.
Formal Description
Interaction-ID: 127

drug/chemical compound

Streptozocin

increases_quantity of

gene/protein

TNF

in serum; under hyperglycemic condition
Drugbank entries Show/Hide entries for Streptozocin or TNF
Comment The addition of arjunolic acid (AA) to STZ treated rats could inhibit or reduce the serum glucose accumulation and decreased the serum NO and TNF-alpha levels.
Formal Description
Interaction-ID: 131

drug/chemical compound

Arjunolic acid

decreases_quantity of

gene/protein

TNF

in serum; in STZ treated rats
Drugbank entries Show/Hide entries for TNF