General Information:

Id: 467
Diseases: Parkinson disease
Homo sapiens
BTO:0002181 HEK-293T cell; BTO:0000793 SH-SY5Y cell
article
Reference: Liou AK et al.(2008) Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway. Neurobiol. Dis. 32: 116-124 [PMID: 18675914]

Interaction Information:

Comment Hydrogen peroxide induces oxidative stress leading to cell death.
Formal Description
Interaction-ID: 2115

drug/chemical compound

H2O2

increases_activity of

Comment Hydrogen peroxide induces oxidative stress leading to cell death.
Formal Description
Interaction-ID: 2130

increases_activity of

process

neuron death

Comment Wildtype LRRK2 but not LRRK2-Y1699C mutant activated the ERK1/2 pathway and thereby protected against H2O2-induced cell death.
Formal Description
Interaction-ID: 2132

gene/protein

LRRK2

increases_activity of

Comment Wildtype LRRK2 but not LRRK2-Y1699C mutant activated the ERK1/2 pathway and thereby protected against H2O2-induced cell death.
Formal Description
Interaction-ID: 2133

gene/protein mutant

LRRK2-p.Y1699C

NOT increases_activity of

Comment Wildtype LRRK2 but not LRRK2-Y1699C mutant activated the ERK1/2 pathway and thereby protected against H2O2-induced cell death.
Formal Description
Interaction-ID: 4409

decreases_activity of

if oxidative stress has been induced by H2O2