General Information:

Id: 466 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Drosophila melanogaster
BTO:0000142 brain
article
Reference: Tain LS et al.(2009) Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss Nat. Neurosci. 12: 1129-1135 [PMID: 19684592]

Interaction Information:

Comment Overexpression of 4E-BP in Pink1 and park mutants was capable of significantly suppressing dopaminergic neuron loss. This indicates that 4E-BP mediates a protective mechanism that is sufficient to prevent the pathologic consequence of loss of parkin or Pink1.
Formal Description
Interaction-ID: 2113

gene/protein

EIF4EBP1

decreases_activity of

process

neuron death

if 4E-BP is overexpressed in parkin mutant
Comment Overexpression of 4E-BP in Pink1 and park mutants was capable of significantly suppressing dopaminergic neuron loss. This indicates that 4E-BP mediates a protective mechanism that is sufficient to prevent the pathologic consequence of loss of parkin or Pink1.
Formal Description
Interaction-ID: 2116

gene/protein

EIF4EBP1

decreases_activity of

process

neuron death

if 4E-BP is overexpressed in Pink1 mutant
Comment Addition of Rapamycin suppressed neuron degeneration in parkin and Pink1 mutants. Rapamycin did not prevent neurodegeneration in 4e-BP mutants suggesting that effects of rapamycin are mediated by 4E-BP.
Formal Description
Interaction-ID: 2124

drug/chemical compound

Rapamycin

decreases_activity of

process

neuron death

Comment Thor and park double mutants were essentially lethal. This lethality could be rescued by targeted expression of 4E-BP.
Formal Description
Interaction-ID: 4007

gene/protein

PARK2

decreases_activity of

process

neuron death

Comment Thor and park double mutants were essentially lethal. This lethality could be rescued by targeted expression of 4E-BP.
Formal Description
Interaction-ID: 4008

gene/protein

EIF4EBP1

decreases_activity of

process

neuron death

in Thor and park double mutants