General Information:

Id: 4,660 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Schizophrenia - [OMIM]
Reference: Kong KC and Tobin AB(2011) The role of M(3)-muscarinic receptor signaling in insulin secretion Commun Integr Biol 4: 489-491 [PMID: 21966580]

Interaction Information:

Comment The non-specific muscarinic receptor agonist, carbachol, when administered intravenously, not only potentiated glucose-stimulated insulin secretion in mice fed with either a control or a high-fat diet, but also normalized glucose-stimulated insulin secretion and glucose tolerance in mice subjected to a high-fat diet. This study led to the proposal that the development of islet-specific muscarinic agonists, with lesser general muscarinic activity, might be a feasible target to improve insulin secretion in type II diabetes.
Formal Description
Interaction-ID: 46453

drug/chemical compound


increases_activity of

in pancreas, in pancreatic islets
Drugbank entries Show/Hide entries for Carbachol