General Information:

Id: 460 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0000007 HEK-293 cell
article
Reference: Gal J et al.(2009) Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism J. Neurochem. 111: 1062-1073 [PMID: 19765191]

Interaction Information:

Comment p62 acts as an adaptor between mutant SOD1 and the autophagy machinery. Mutant SOD1 can be recognized by p62 in an ubiquitin-independent fashion and targeted for the autophagy-lysosome degradation pathway.
Formal Description
Interaction-ID: 2074

gene/protein

SQSTM1

affects_activity of

process

autophagy