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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	460 (click here to show other Interactions for entry)
Diseases:	Amyotrophic lateral sclerosis
Organism:	Homo sapiens
Tissue/Cell line:	BTO:0000007 HEK-293 cell
Publication type:	article
Reference:	Gal J et al.(2009) Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism J. Neurochem. 111: 1062-1073 [PMID: 19765191]

Interaction Information:

Comment	p62 acts as an adaptor between mutant SOD1 and the autophagy machinery. Mutant SOD1 can be recognized by p62 in an ubiquitin-independent fashion and targeted for the autophagy-lysosome degradation pathway.
Formal Description Interaction-ID: 2074	gene/protein SQSTM1 affects_activity of process autophagy

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