General Information:

Id: 459 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Peutz-Jeghers syndrome - [OMIM]
Mus musculus
male
adenovirus-mediated deletion of LKB1 in liver
article
Reference: Shaw RJ et al.(2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310: 1642-1646 [PMID: 16308421]

Interaction Information:

Comment LKB1 loss results in increased gluconeogenetic and lipogenic gene expression.
Formal Description
Interaction-ID: 2036

gene/protein

STK11

affects_activity of

process

gluconeogenesis

Comment TORC2 is deregulated in LKB1-deficient livers and drives gluconeogenesis.
Formal Description
Interaction-ID: 12749

gene/protein

CRTC2

affects_activity of

process

gluconeogenesis

Comment AMPK activation is absolutely required for the glucose-lowering action of metformin in intact animals. The deletion of LKB1 in the liver did not impair AMPK activation in muscle, yet it eliminated the effect of metformin on serum glucose levels. This result suggests that in mice, metformin primarily decreases blood glucose concentrations by decreasing hepatic gluconeogenesis.
Formal Description
Interaction-ID: 12753

drug/chemical compound

Metformin

decreases_activity of

process

gluconeogenesis

in liver
Drugbank entries Show/Hide entries for Metformin