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Diseases	Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	459 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance Peutz-Jeghers syndrome - [OMIM]
Organism:	Mus musculus
Gender:	male
Organism Model:	adenovirus-mediated deletion of LKB1 in liver
Publication type:	article
Reference:	Shaw RJ et al.(2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310: 1642-1646 [PMID: 16308421]

Interaction Information:

Comment	TORC2 is deregulated in LKB1-deficient livers and drives gluconeogenesis.
Formal Description Interaction-ID: 12749	gene/protein CRTC2 affects_activity of process gluconeogenesis

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